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CDKN1A — UCN

Text-mined interactions from Literome

Abe et al., Gan To Kagaku Ryoho 2000 : While p21 protein expression was induced by UCN-01 in both CRL 1420 and MX-1, an accumulation of dephosphorylated ppRb was observed only in CRL 1420, resulting in G1 block as detected by flow cytometric analysis
Dai et al., Cancer Res 2001 (Leukemia...) : Lastly, although UCN-01 +/- PD184352 did not induce p21 ( CIP1 ), stable expression of a p21 ( CIP1 ) antisense construct significantly increased susceptibility to this drug combination
Sampath et al., Mol Pharmacol 2002 : UCN-01 also had no effect on the association of p21 with Cdk2
Facchinetti et al., Cancer Res 2004 (MAP Kinase Signaling System) : Moreover, UCN-01 promoted the accumulation of p21 at the mRNA level in the p53-deficient HaCaT cells without increase in the p21 mRNA half-life, suggesting that UCN-01 induced p21 at the transcriptional level ... To study UCN-01 transcriptional activation of p21 , we used several p21 ( waf1/cip1 ) promoter-driven luciferase reporter plasmids and observed that UCN-01 activated the full-length p21 ( waf1/cip1 ) promoter and a construct lacking p53 binding sites ... Neither protein kinase C nor PDK1/AKT pathways were relevant for the induction of p21 by UCN-01
Wu et al., BMC cancer 2013 (Carcinoma, Hepatocellular...) : UCN-01 induces S and G2/M cell cycle arrest through the p53/p21 ( waf1 ) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines