Gene interactions and pathways from curated databases and text-mining

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CXCL16 — MMP2

Text-mined interactions from Literome

Hu et al., Cancer Sci 2008 (Neoplasm Invasiveness...) : Furthermore, in contrast to CXCL12, which enhanced the activity of matrix metalloproteinase (MMP) 9 and MMP2 in PC3 and LNCap, CXCL16 ligation resulted in stronger MMP9 and MMP2 activity in LNCap but not in PC3 ... Furthermore, in contrast to CXCL12, which enhanced the activity of matrix metalloproteinase (MMP) 9 and MMP2 in PC3 and LNCap, CXCL16 ligation resulted in stronger MMP9 and MMP2 activity in LNCap but not in PC3
Jovanović et al., Reproduction 2010 : Exogenous IL8/CXCL8 increased trophoblast cell migration and invasion, which may be partly attributable to stimulation of MMP2 and MMP9 levels and an increase in integrins
Laird et al., Hum Reprod 2011 : In contrast to its effects in other cells, CXCL12 had no effect on MMP-2 or MMP-9 production by endometrial stromal or epithelial cells
Takekoshi et al., Mol Cancer Ther 2012 (Lung Neoplasms...) : In vitro analysis of amino-terminal cleavage by enzymes dipeptidylpeptidase IV ( DPPIV/CD26 ) and matrix metalloproteinase-2 (MMP-2) resulted in 25-fold and 2-fold slower degradation rates, respectively, of CXCL122 compared with wtCXCL12
Zhang et al., Hum Reprod 2013 : However, CXCL6 inhibited trophoblast cell migration and invasion by suppressing MMP-2 activity in human first-trimester interface