Lo et al., EMBO J 2001
:
Here we show that TGIF levels modulate sensitivity to TGF-beta mediated growth inhibition, that TGIF is a short lived protein and that epidermal growth factor (EGF) signaling via the Ras-Mek pathway causes the phosphorylation of TGIF at two Erk MAP kinase sites, leading to TGIF stabilization and favoring the formation of Smad2-TGIF co-repressor complexes in response to TGF-beta
Yang et al., Am J Physiol Lung Cell Mol Physiol 2008
(MAP Kinase Signaling System) :
We show that EGF does not prevent the TGF-beta induced nuclear accumulation of Smad2/3 ; rather, EGF stabilizes the short lived Smad transcriptional corepressor TG-interacting factor (TGIF) via EGFR/Mek/Erk mediated phosphorylation of TGIF