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EGF — NOS3

Text-mined interactions from Literome

Zheng et al., Endocrinology 1999 : As the mitogen activated protein kinase ( MAPK ) signal cascade has been widely associated with cell growth in response to growth factors, herein we investigate whether bFGF, EGF , and VEGF also stimulate expression of endothelial nitric oxide synthase (eNOS) via activation of the MAPK cascade in ovine fetoplacental artery endothelial cells ... Maximal stimulatory effects of bFGF and EGF on eNOS protein expression were observed at 10 ng/ml for 24 h of treatment and were associated with elevated eNOS messenger RNA ... PD 98059 also significantly inhibited bFGF- and EGF induced increases in eNOS protein expression ... Because treatment with all three growth factors resulted in activation of the MAPK cascade, while bFGF and EGF, but not VEGF, increased eNOS expression, we conclude that activation of the MAPK cascade is necessary, but not sufficient, for bFGF- and EGF induced increases in eNOS protein expression in ovine fetoplacental artery endothelial cells
Rokutan et al., J Gastroenterol 2000 : In contrast, GGA and EGF induced neuronal NOS, but not endothelial NOS , which was confirmed by immunoblot analyses with antibodies against these constitutive NOS isoforms
Erickson et al., Urology 2001 (Cystitis, Interstitial) : Markers that changed after treatment were as follows : ( 1 ) nitric oxide synthase and cyclic guanosine monophosphate increased with oral L-arginine ; ( 2 ) ECP decreased with subcutaneous heparin ; ( 3 ) prostaglandin E ( 2 ) and kallikrein decreased after bladder distention ; ( 4 ) neutrophil chemotactic activity decreased after dimethyl sulfoxide ; ( 5 ) IL-2 inhibitor decreased after oral nifedipine ; ( 6 ) IL-2, IL-6, and IL-8 decreased after bacille Calmette-Guérin ( BCG ) vaccine ; and ( 7 ) APF and heparin binding epidermal growth factor changed to or toward normal levels after bladder distention or sacral nerve stimulation
Wartenberg et al., Int J Cancer 2003 (Prostatic Neoplasms) : Furthermore, eNOS expression was increased by epidermal growth factor (EGF) in a redox-sensitive manner
Boissel et al., J Invest Dermatol 2004 : The neuronal nitric oxide synthase is upregulated in mouse skin repair and in response to epidermal growth factor in human HaCaT keratinocytes
Gifford et al., J Endocrinol 2004 (Calcium Signaling) : ATP, basic fibroblastic growth factor (bFGF), EGF and VEGF induced mitogenesis and caused a rise in ERK 2 activation within 10 min. L-Arginine to L-citrulline conversion assays showed that ATP, EGF and VEGF induced a significant rise in eNOS activity, and this correlates with an ability to induce Ca2+ mobilization and ERK 2 activation
Niidome et al., Eur J Pharmacol 2006 : We also investigated the effects of glutamate receptor antagonists, antioxidants and nitric oxide synthase inhibitor on EGF deprivation induced cell death
Mehta et al., Growth Factors 2007 (MAP Kinase Signaling System) : HB-EGF- and EGF induced HUVEC migration and capillary tube formation were dependent upon activation of PI3K, MAPK and eNOS
Mei et al., Hepatology 2011 (MAP Kinase Signaling System) : EGF induced eNOS phosphorylation at Ser 1177 is dependent on the phosphorylation and activation of EGFR/PI3 kinase/AKT signaling in hepatocytes