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BRCA1 — CDKN1A

Text-mined interactions from Literome

Li et al., Nature 2000 : BRCA1 also directly interacts with proteins of the DNA repair machinery and regulates expression of both the p21 and GADD45 genes
Lu et al., Oncogene 2000 (Breast Neoplasms...) : Two cell lines with wildtype p53 ( MCF-7 and MCF10A ) demonstrated transcriptional activation of the p21 promoter by full-length BRCA1 ( BRCA1L ) as well as by two splice variants that lack most of exon 11 ( BRCA1S and BRCA1S-9,10 )
Moisan et al., J Biol Chem 2006 : We further show that BRCA1 rescues the UV-mediated inhibition of transcriptional activity from nuclear extracts and stimulates endogenous p21 gene expression upon UV irradiation, a function that is dependent of the inhibition of CTD kinase activity ... Our results suggest that BRCA1 could act as a CTD kinase inhibitor and, as such, contribute to the regulation of p21 gene expression
Somasundaram et al., Nature 1997 : Here we show that BRCA1 transactivates expression of the cyclin dependent kinase inhibitor p21WAF1/CIP1 in a p53 independent manner, and that BRCA1 inhibits cell-cycle progression into the S-phase following its transfection into human cancer cells
Sourvinos et al., Biochem Biophys Res Commun 1998 (Breast Neoplasms) : Samples exhibiting reduced BRCA1 levels simultaneously overexpressed both p21 and mdm-2, showing that BRCA1 , at certain levels, even reduced up to 2.7-fold, is functional and sufficient to upregulate p21 , when p53 activity is inhibited by its negative regulator, the mdm-2