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LPA — PXN

Text-mined interactions from Literome

Imamura et al., Jpn J Cancer Res 2000 (Carcinoma, Hepatocellular...) : Y-27632 suppressed LPA induced tyrosine phosphorylation of FAK and paxillin , suggesting that ROCK regulates these molecules and Y-27632 inhibits cellular migration and morphological change, at least in part, through this regulation
Saito et al., Jpn J Ophthalmol 2004 : LPA induced a concentration- and time dependent increase in the tyrosine phosphorylation of paxillin, which was maximal at a concentration of 10 micro M and a time of 2 min. Exoenzyme C3 inhibited LPA induced paxillin phosphorylation ... LPA induces Rho activation and the consequent tyrosine phosphorylation of paxillin in HCE cells, and these effects likely contribute to the promotion of corneal epithelial migration by this agent
Ogata et al., Int J Gynecol Cancer 2009 (Carcinoma...) : Fasudil suppressed LPA induced tyrosine phosphorylation of paxillin , a representative focal adhesion protein, and serine phosphorylation of myosin light chain, which are essential for the process for cell migration
Cheng et al., Int Endod J 2011 : LPA also increased the level of tyrosine phosphorylation of paxillin at 30min ( P < 0.05 ) and FAK at 5 and 30min ( P < 0.05 ) ... Furthermore, p-paxillin levels declined immediately after Y-27632 treatment and remained low at 5, 30, 60min. Y-27632 also suppressed the effects of LPA on p-paxillin and p-FAK at 5 and 30min ( P < 0.05 )
Wang et al., Biochem J 1997 (Second Messenger Systems) : Similarly, PMA also decreased LPA induced tyrosine phosphorylation of p125(FAK) and paxillin without abrogating the response to SPP