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APEX1 — JUN

Text-mined interactions from Literome

Fritz et al., Oncogene 1999 : Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1 ... Inhibition of CKII mediated phosphorylation of APE/Ref-1 blocked mutagen stimulated increase in AP-1 binding
Diamond et al., J Biol Chem 1999 : Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock ... Electrophoretic mobility shift assay extracts immunodepleted of Ref-1 protein demonstrated that the increase in AP-1 DNA binding activity following heating was dependent upon the presence of Ref-1 and that Ref-1 regulates inducible, but not basal, AP-1 DNA binding activity ... The ability of Ref-1 from heated cells to stimulate AP-1 DNA binding was abolished by chemical oxidation and restored by chemical reduction
Monick et al., J Biol Chem 1999 : There was, however, a significant difference in the amounts of the nuclear protein, REF-1 ( which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins ), in alveolar macrophages compared with monocytes
Arnér et al., Eur J Biochem 2000 : A growing number of transcription factors including NF-kappaB or the Ref-1 dependent AP1 require thioredoxin reduction for DNA binding
Yan et al., Biochem Biophys Res Commun 2000 : Gel shift assays of nuclear extracts immunodepleted of Ref-1 protein demonstrated that IL-2 induced AP-1 DNA binding is dependent on the presence of Ref-1 ... Additionally, reporter gene assays showed that AP-1 transcriptional activity was enhanced by the overexpression of Ref-1 and attenuated by the introduction of antisense Ref-1
Wei et al., Cancer Res 2000 : In addition, immunodepletion of Ref-1 from nuclear extracts demonstrated that the increase in AP-1 DNA binding activity after IR was also dependent upon the presence of Ref-1 from irradiated cells ... Finally, the ability of both TRX and Ref-1 from irradiated cells to stimulate AP-1 DNA binding in nonirradiated nuclear extracts was abolished by chemical oxidation and restored by chemical reduction
Robertson et al., Cancer Res 2001 (Carcinoma, Embryonal...) : Moreover, Ape1/ref-1 stimulates the DNA binding activity of transcription factors ( Fos-Jun , nuclear factor-kappaB, Myb, ATF/cyclic AMP-responsive element binding protein family, HIF-1alpha, HLF, PAX, and p53 ) through a redox mechanism and thus represents a novel component of signal transduction processes that regulate eukaryotic gene expression
Guo et al., Am J Transplant 2004 (Liver Diseases...) : Interestingly, Ref-1 significantly increased DNA binding of Stat3, but not AP-1
Ding et al., Gastroenterology 2004 (Campylobacter Infections...) : H. pylori or H 2 O 2 also induced nuclear accumulation of APE-1/Ref-1, and overexpression of APE-1/Ref-1 increased activator protein 1 binding activity
Yang et al., Mol Cancer Ther 2005 (Melanoma) : In vitro studies revealed that resveratrol inhibited, in a dose dependent manner, Ref-1 activated activator protein-1 DNA binding activities as well as Ref-1 endonuclease activities and rendered melanoma cells more sensitive to dacarbazine treatment
O'Hara et al., J Immunol 2006 (Helicobacter Infections) : Small interfering RNA mediated silencing of APE-1/Ref-1 inhibited basal and H. pylori induced AP-1 and NF-kappaB DNA binding activity without affecting the nuclear translocation of these transcription factors and also reduced H. pylori induced IL-8 mRNA and protein
DeMorrow et al., Am J Physiol Gastrointest Liver Physiol 2008 (Hyperplasia) : Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Wang et al., Biochim Biophys Acta 1994 : The effect of dithiothreitol is opposite to that observed for the Ref-1 mediated binding of Fos/Jun to the ARE or to the related 12-O-tetradecanoyl phorbol-13-acetate responsive element ( TRE )
Hirota et al., Proc Natl Acad Sci U S A 1997 : AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1 ... We here report the molecular cascade of redox regulation of AP-1 mediated by TRX and Ref-1
Asai et al., Biochem Biophys Res Commun 1997 : These results suggested that increased Ref-1 by TSH might regulate the binding activity of AP-1 in thyroid cells