◀ Back to TNF
AGTR1 — TNF
Text-mined interactions from Literome
Knoblach et al., J Neuroimmunol 1999
(Brain Injuries) :
TNF alpha levels
increased significantly in the injured cortex
at 1 and 4, but not at 12, 24 or 72 h after severe lateral fluid-percussion trauma ( 2.6-2.7 atm )
Szuster-Ciesielska et al., Toxicology 2000
:
Cadmium ions
at 1 and 10 microM concentration, used alone
induced a low, but detectable
TNF activity in BAECs, and zinc ions at 1, 10 and 100 microM concentration induced both IFN and TNF activity
Cowling et al., J Biol Chem 2002
:
These results suggest that low but persistent IKK activity and I kappa B degradation lead to prolonged NF-kappa B nuclear translocation and maximal
AT(1) up-regulation in the continued
presence of
TNF-alpha
Peng et al., Circ Res 2002
(Cardiomyopathies...) :
Tumor necrosis factor-alpha induced
AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis ... We sought to determine if
TNF-alpha induced
AT1 receptor upregulation alters fibroblast responsiveness to Ang II and if this effect differs from direct TNF-alpha effects on fibroblast functions ... In cardiac fibroblasts with
TNF-alpha induced
AT1 receptor upregulation, Ang II-stimulated [ 3H ] proline incorporation and TIMP-1 protein production was approximately 2-fold greater than in nonpretreated fibroblasts ... Thus,
TNF-alpha induced
AT1 receptor upregulation enhances Ang II-mediated functions that favor fibrosis
Siragy et al., Endocrinology 2003
(Albuminuria...) :
AT(1) receptor blockade with valsartan
prevented the increase in
TNF-alpha in the diabetic group
Meli et al., J Neuroimmunol 2004
(Disease Models, Animal...) :
At 1 mg/kg q6h TNF484
reduced soluble
TNF-alpha and the collagen degradation product hydroxyproline in the cerebrospinal fluid
Berthonneche et al., Cardiovasc Drugs Ther 2005
(Myocardial Infarction...) :
Since
Angiotensin II type 1 (AT1) receptor can be
involved in
TNF-alpha production, we have investigated whether early short-term treatment with irbesartan, an AT1 receptor blocker, is able to limit TNF-alpha production within the heart and to improve cardiac function and geometry following MI in rats
Yayama et al., Biol Pharm Bull 2006
:
These results suggest that the up-regulation of cardiac B2-receptor expression by LPS is mediated through
TNF-alpha , which is produced in the myocardium by two different mechanisms in an
AT1-receptor dependent and independent manners, implying the role of the cardiac kallikrein-kinin system in the development of cardiac dysfunction during sepsis
LaMarca et al., Hypertension 2008
(Hypertension, Pregnancy-Induced...) :
The purpose of this study was to determine the
role of placental ischemia and
TNF-alpha in stimulating the
AT1-AA and the importance of AT1 receptor activation in mediating hypertension during reductions in uterine perfusion pressure ( RUPP ) and chronic TNF-alpha excess in pregnant rats
Maeda et al., Int Immunopharmacol 2009
:
Moreover, the production of IFN-gamma and
TNF-alpha through CTL stimulation can be
inhibited by the selective
AT1R inhibitor, Losartan
Zhou et al., Circulation 2010
(Neovascularization, Pathologic...) :
Our findings demonstrate that
AT(1)-AA mediated
tumor necrosis factor-alpha induction, by overcoming its negative regulator, heme oxygenase-1, is a key underlying mechanism responsible for impaired placental angiogenesis by inducing both sEng and soluble fms-like tyrosine kinase-1 secretion from human villous explants
Ulich et al., Am J Pathol 1990
:
Endotoxin ( Salmonella typhus lipopolysaccharide ) injected intravenously
induces little or no increase in whole-organ
TNF mRNA levels at 15 ', 30 ', 1 degree, 2 degrees, or 4 degrees, whereas serum TNF levels are markedly elevated
at 1 and 2 hours
Lv et al., Braz J Med Biol Res 2012
:
In the PS group,
TNF-a increased
at 1 , 3, and 5 weeks and IL-1ß increased significantly after 1 and 3 weeks of stress, and then decreased to normal levels by 5 weeks
Chai et al., Acta Biochim Biophys Sin (Shanghai) 2012
(Pre-Eclampsia) :
AT1-AA increased
TNF secretion and caspase-3 activities ... AT1 receptor blockade completely abrogated
AT1-AA induced
TNF-a secretion, caspase-3 activation, and cardiomyocyte apoptosis
Gasparotto et al., Sci Total Environ 2013
:
However, CFA
at 1mg/mL induced an increase of approximately 338 % in intracellular
TNF-a , while release of this proinflammatory cytokine was increased by 1.6-fold
Sasamura et al., Hypertension 1997
:
We therefore examined the
effects of interleukin-1 alpha ( 220 U/mL [ 10 ng/mL ] ),
tumor necrosis factor-alpha ( 280 U/mL [ 100 ng/mL ] ), and interferon gamma ( 100 U/mL ) on
Ang II type 1 (AT1) receptors expressed in rat vascular smooth muscle cells ...
Tumor necrosis factor-alpha and interferon gamma did not
cause a significant change in
AT1 binding when administered alone but caused a 30 % reduction in binding when administered together ( P < .05 )
Meng et al., Am J Physiol 1998
(Endotoxemia) :
Circulating and myocardial
TNF-alpha increased
at 1 and 2 h, whereas myocardial contractility was depressed at 4 and 6 h. Pretreatment with cycloheximide or dexamethasone abolished the increase in circulating and myocardial TNF-alpha and preserved myocardial contractile function
Chen et al., Biol Reprod 1999
:
TNFalpha significantly
inhibited hCG/PRL induced StAR and LHR mRNA expression
at 1 and 3 h post-TNFalpha