◀ Back to SMAD7
MAP2K3 — SMAD7
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAP2K3
→
SMAD7
(increases)
Edlund et al., Mol Biol Cell 2003
Evidence: Treatement of antisense Smad7 (AS-S7) transfected PC-3U cells with TGF-beta1 for 15 min to 24 hour did not lead to phosphorylation of MKK3/6 whereas a stronger signal for phosphorylated MKK3/6 was observed in lysates from PC-3U cells infected with adenoviral Flag-Smad7.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Edlund et al., Mol Biol Cell 2003
(Prostatic Neoplasms) :
Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves
Smad7 dependent
activation of p38 by TGF-beta activated kinase 1 and
mitogen activated protein kinase kinase 3
Chen et al., Exp Cell Res 2010
:
Inhibition of
mitogen activated protein kinase kinase 1 ( MEK 1 ) either directly with PD98059 or with MEK 1 siRNA resulted in
inhibition of EPO mediated suppression of EMT and
Smad signal transduction in TGF-beta1 treated cells