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PIK3CA — VCAM1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lazaar et al., J Immunol 2001
:
VCAM-1 engagement also
stimulated a rapid increase in
PI3K activity
Amin et al., Blood 2006
:
Antisense oligodeoxynucleotides ( ODNs ) and inhibitors of Src,
PI3K , p38, and NFkappaB significantly
reduced rhMIF induced MN
VCAM-1 and ICAM-1 expression ( P < .05 )
Fritz et al., J Immunol 2006
:
Induction of
VCAM-1 by OSM was
diminished by pharmacological inhibitors of
PI3K ( LY294002 ) but not inhibitors of ERK1/2 ( PD98059 ) or p38 MAPK ( SB203580 )
Tung et al., Cell Signal 2007
:
In this study, we identified a
requirement for PDGFR,
PI3-K/Akt , p38 MAPK, JNK, and NF-kappaB in the regulation of
VCAM-1 expression by rat vascular smooth muscle cells ( VSMCs ) in response to viral infection
Lin et al., Toxicol Appl Pharmacol 2008
:
LPS stimulated Src, PYK2, EGFR, and Akt phosphorylation and
VCAM-1 expression were
attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ),
PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110