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EPHB2 — FRS3

Text-mined interactions from Literome

Huang et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation ... SNT-2 downregulates ERK2 phosphorylation, suppresses and delays ERK2 nuclear accumulation which occurs following EGF stimulation ... These observations suggest that SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2
Huang et al., Oncogene 2006 : We previously reported that SNT-2 is not tyrosine phosphorylated significantly in response to epidermal growth factor (EGF) but that it inhibits ERK activation via EGF stimulation by forming a complex with ERK2