Gene interactions and pathways from curated databases and text-mining

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MMP9 — TNFRSF11B

Text-mined interactions from Literome

Wittrant et al., Biochem Biophys Res Commun 2002 : This study investigated the direct effects of human OPG on cathepsin K, MMP-9 , MMP-2, and tissue inhibitors of metalloproteinases ( TIMP1 and TIMP2 ) expressed by purified rabbit osteoclasts
Wittrant et al., Exp Cell Res 2004 : In these experimental conditions, OPG induced MMP-9 inhibition was abrogated in the presence of a blocking anti-RANKL antibody, suggesting that part of OPG effects are RANKL dependent
Bennett et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis...) : In vitro, OPG induced matrix metalloproteinase-9 (MMP-9) activity in macrophages and smooth muscle cells and acted as a survival factor for serum deprived smooth muscle cells
Zhang et al., Bone 2009 (Weight Gain) : Ovariectomy promoted the mRNA expression of alpha-1 type I collagen (COL), osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand ( RANKL ) ; and inhibited the mRNA expression of cathepsin K and matrix metalloproteinase-9 (MMP-9) in the proximal tibia of aged rats