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RAC1 — RASA1

Text-mined interactions from Literome

Sheffield et al., Acta Crystallogr D Biol Crystallogr 1999 : This GAP activates RhoA and Cdc42Hs, but not Rac
Borg et al., FEBS Lett 1999 : Plant cell growth and differentiation may involve GAP regulation of Rac activity
Okamoto et al., Mol Cell Biol 2000 : In EDG5 cells, S1P stimulated PI 3-kinase activity as it did in EDG1 cells but inhibited the basal Rac activity and totally abolished IGF I-induced Rac activation, which involved stimulation of Rac-GTPase activating protein activity rather than inhibition of Rac-guanine nucleotide exchange activity
Zhang et al., J Biol Chem 2001 : Oligomerization of Rac1-GTP led to a self-stimulatory GTPase activating protein (GAP) activity, resulting in a significantly enhanced intrinsic GTP hydrolysis rate of Rac1-GTP
Takuwa et al., Biochim Biophys Acta 2002 : Edg5 mediated Rac inhibition involves stimulation of Rac-GTPase activating protein (GAP) activity, rather than inhibition of Rac-guanine nucleotide exchange factor (GEF) activity
Moskwa et al., J Biol Chem 2005 : Removal of amino acids 1-48 and 169-197 of p50RhoGAP increases the GAP effect on non prenylated Rac , whereas prenylated Rac reacts equally well with the full-length and the truncated proteins
Ladhani et al., Neoplasia (New York, N.Y.) 2011 (Neoplasm Invasiveness...) : These changes in cell shape depended on decreased RhoA and increased Rac1 activation and were mediated by the up-regulation of Rac1-GEF, DOCK3 and down-regulation of Rac1-GAP , ARHGAP22
David et al., Arterioscler Thromb Vasc Biol 2011 : Angiopoietin-1 requires IQ domain GTPase activating protein 1 to activate Rac1 and promote endothelial barrier defense