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EPHB2 — RNF19A

Text-mined interactions from Literome

Marushige et al., Anticancer Res 1999 (MAP Kinase Signaling System...) : The p38 inhibitor, PD169316, reduced the activities of ERK and Akt
Kimata et al., Biochem Pharmacol 2000 (MAP Kinase Signaling System) : To investigate the roles of these kinase pathways for mediator release from human mast cells, we examined the participation of the activation of these kinases in mediator release, using 1,4-diamino-2, 3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ), an ERK pathway inhibitor, and 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imid azo le ( SB203580 ), a p38 MAPK pathway inhibitor
Wen et al., J Cell Biochem 2000 : On the other hand, rottlerin ( the selective PKCdelta inhibitor ), SB 203580 ( the selective p38 MAPK inhibitor ), and wortmannin ( the PI 3-kinase inhibitor ) can affect neither cPLA(2) nor ERK phosphorylation
Westermarck et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : Specific activation of p38alpha by adenovirus delivered constitutively active MKK3b resulted in potent inhibition of the activity of ERK1,2 and its upstream activator MEK1,2
Maulon et al., Oncogene 2001 (MAP Kinase Signaling System) : These data are consistent with a model where thrombin induces ERK activation via both PKC dependent and independent pathways, whereas p38 MAPK activation requires only PTKs
Yu et al., J Physiol 2001 (MAP Kinase Signaling System) : ERK1/2 phosphorylation increased 7.8-fold and p38 MAPK phosphorylation increased 4.4-fold post-exercise
Markou et al., Biochem J 2002 : Phosphorylation and activation of MSK1 was completely inhibited by either PD98059 ( ERK1/2 pathway inhibitor ) or SB203580 ( p38 MAPK inhibitor ) alone
Pruitt et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : Rather surprisingly, we found that pharmacologic inhibition of p38 , together with Raf activation of ERK , was sufficient to mimic the morphologic and growth transformation caused by oncogenic Ras
Hall et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : Moreover, p38 inhibition upregulates JNK and ERK activity in M1 cells and in thioglycollate elicited peritoneal exudate macrophages ... Thus, we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and ERK activity and inhibit IL-10 expression
Wu et al., J Biol Chem 2003 : SB203580, a p38 MAPK inhibitor, and PD98059, an ERK inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor, prevented AA toxicity in pyrazole hepatocytes and E47 cells
Wang et al., Am J Physiol Heart Circ Physiol 2003 (MAP Kinase Signaling System) : ERK was not activated by force, but p38 phosphorylation was required for force induced inhibition of SMA expression
Schaefer et al., Cell Signal 2004 (Leukemia, Erythroblastic, Acute...) : The p38 inhibitor SB 203580 enhanced ERK1/2 phosphorylation and egr-1 mRNA levels
Peng et al., Circulation 2005 (Cardiomyopathies) : NADH oxidase activation by LPS increased ERK1/2 and p38 phosphorylation, and inhibition of ERK1/2 and p38 phosphorylation blocked the effect of NADH oxidase on TNF-alpha expression
Chialda et al., Respir Res 2005 (Asthma...) : By means of specific inhibitors we showed that p38 and ERK act downstream of CD28 and that ERK and JNK act downstream of ICOS leading to the induction of various T cell derived cytokines
Shinkai et al., Am J Physiol Lung Cell Mol Physiol 2006 : The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion
Li et al., Blood 2006 (MAP Kinase Signaling System) : Thus, p38 plays an important role in mediating PKG dependent activation of ERK
Wang et al., Blood 2006 (MAP Kinase Signaling System...) : TCCM treatment activated p38 mitogen activated protein kinase ( MAPK ) and Janus kinase ( JNK ) but inhibited extracellular regulated kinase (ERK)
Wang et al., Mol Cell Biochem 2006 : Our results suggest that p38 affects the phosphorylation of Smad2 and Smad3 differentially during TGF-beta signaling in human dental pulp cells and ERK1/2 might be involved in the process
Usatyuk et al., J Biol Chem 2006 : Pretreatment of BLM-VECs with thiol protectants, N-acetylcysteine and mercaptopropionyl glycine, attenuated 4-HNE induced decrease in transendothelial electrical resistance, reactive oxygen species generation, Michael protein adduct formation, protein tyrosine phosphorylation, activation of ERK , JNK, and p38 MAPK, and actin cytoskeletal rearrangement
Yan et al., Mol Immunol 2007 : Consistently, ERK activation by DOTAP is also negatively regulated by p38
Kim et al., Arch Pharm Res 2007 : We conclude that ERK activation and p38 MAPK inhibition can work in an additive manner to decrease melanogenesis
DU et al., Zhonghua Yu Fang Yi Xue Za Zhi 2007 (MAP Kinase Signaling System) : ERK1/2 , JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations
Wo et al., J Cell Biochem 2008 (MAP Kinase Signaling System) : Treatment with ICA, intracellular ROS in embryoid bodies was rapidly elevated, which was abolished by the NADPH-oxidase inhibitor apocynin ; elimination of intracellular ROS by vitamin E or pyrrolidine dithiocarbamate ( PDTC ) inhibited ICA induced cardiomyogenesis ; ROS-sensitive extracellular regulated kinase 1, 2 ( ERK1 , 2 ) and p38 activation were further observed, the cardiomyogenesis was significantly inhibited in the presence of ERK1, 2 or p38 inhibitor U0126 or SB203580, indicating the roles of NADPH-ROS-MAPKs signaling cascades in prenylflavonoids induced cardiac differentiation
Nielsen et al., Am J Physiol Cell Physiol 2008 : It is thus likely that cell swelling via activation of ERK1/2 and cell shrinkage via activation of the p38 and JNK pathway and inhibition of the PDGFR signaling pathway may act as key players in the regulation of tissue homeostasis
Tephly et al., Am J Respir Cell Mol Biol 2008 (Asbestosis) : More specifically, p38 was constitutively active and ERK activation was suppressed
Kano et al., Neurochem Res 2008 (MAP Kinase Signaling System) : Interestingly, inhibition of ERK by U0126 completely prevented artepillin C-induced p38 MAPK phosphorylation of PC12m3 cells
Ogunwobi et al., Am J Gastroenterol 2008 (Adenocarcinoma...) : Simvastatin inhibited activation of extracellular signal regulated kinase ( ERK ) and protein kinase B ( Akt ) but not c-Jun NH ( 2 ) -terminal kinase or p38 mitogen activated protein ( MAP ) kinase
De Backer et al., Gut 2009 (Ileus...) : These protective effects are, at least in part, mediated through induction of HO-1, in a p38 dependent manner, as well as reduction of ERK1/2 activation
Tannerstedt et al., J Appl Physiol 2009 : Phosphorylation of ERK1/2 was elevated six- to sevenfold ( P < 0.05 ) immediately after exercise, and p38 MAPK phosphorylation was increased three- to fourfold ( P < 0.05 ) for as long as 1 h after exercise in both types of fibers, although the level was markedly higher in type II fibers ( P < 0.05 )
Sol et al., Lipids in health and disease 2009 : At this time point phosphorylation of mitogen activated protein kinase ( MAPK ) p38 had doubled but ERK1/2 and JNK were not activated
Hu et al., Am J Physiol Cell Physiol 2009 : Pretreatment with PD-98059 ( an ERK inhibitor ) and SB-203580 ( a p38 MAPK inhibitor ) significantly inhibited IL-1beta induced RGS4 expression
Figueiredo et al., FEBS J 2009 (MAP Kinase Signaling System) : We also show that p38 affects ERK via secreted IL-10 ( autocrine crosstalk )
Geest et al., J Leukoc Biol 2009 (MAP Kinase Signaling System) : It has been demonstrated that ERK , JNK, and p38MAPK activity can be regulated in response to a plethora of hematopoietic cytokines and growth factors that play critical roles in hematopoiesis
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : HF6-FC exerts its inhibitory effects by suppression of p38 and NF-kappaB but activation of ERK
van Houdt et al., Cell Oncol 2010 (Colorectal Neoplasms) : MEK inhibition or ERK1/2 suppression caused activation of p38alpha in a K-ras dependent manner
Jiang et al., Int J Mol Med 2010 (MAP Kinase Signaling System) : We found that U0126, a specific inhibitor of ERK1/2 , and SB203580, a specific inhibitor of p38 , down-regulated the TGF-beta1 induced phosphorylation of Smad2 at both linker and C-terminal sites in rat mesangial cells
Jeong et al., Food Chem Toxicol 2010 : Saponins from the roots of Platycodon grandiflorum stimulate osteoblast differentiation via p38 MAPK- and ERK dependent RUNX2 activation
Gorina et al., Glia 2011 : p38 exerted a strong influence on LPS induced gene expression by regulating the phosphorylation of Stat1 and the transcriptional activity of NF?B, while JNK regulated the Jak1/Stat1 pathway, and ERK1/2 controlled the expression of Egr-1 and influenced MyD88 dependent MMP-9 expression
Rossi et al., Eur J Cancer 2011 (MAP Kinase Signaling System...) : DnACTRIIb dependent differentiation of RD cells correlated with a reduced SMAD2/3 ( small mother against decapentaplegic ) and ERK signalling and the activation of p38 pathway
Zhang et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Remarkably, MKP3, ERK2, and phosphorylated p38a can form a stable ternary complex in solution, and the phosphatase activity of MKP3 toward p38a substrate is allosterically regulated by ERK2-MKP3 interaction
Gimenez et al., Parasitology 2013 (Babesiosis...) : Regarding signalling pathways, we here report that LA induced a significant phosphorylation of p38 and extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) whereas LV only induced a reduced activation of ERK1/2
Berra et al., J Biol Chem 1998 : The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway ... We show that the simple inhibition of ERK basal activity is sufficient to trigger apoptosis and p38 activation with no changes in Jun N-terminal kinase/stress activated protein kinase