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MDM2 — TP63

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP63 → MDM2 (increases) Calabrò et al., J Biol Chem 2002*
  Evidence: We show here that like p53, the p63alpha and p63gamma isoforms are able to associate with human MDM2 (HDM2). Overexpression of HDM2 increased the steady-state level of intracellular p63 and enhanced its transcriptional activity. Both effects appeared to be counteracted by ARF coexpression. These data indicate that p63 can be activated by HDM2 under conditions in which p53 is inhibited.
• NCI Pathway Database Validated transcriptional targets of deltaNp63 isoforms: MDM2 (MDM2) → dNp63a (tetramer) complex (TP63) (modification, activates)
  Galli et al., J Cell Sci 2010*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Validated transcriptional targets of deltaNp63 isoforms: MDM2 (MDM2) → dNp63a (tetramer) complex (TP63) (modification, activates)
  Galli et al., J Cell Sci 2010*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — TP63 (physical association, affinity chromatography technology) Galli et al., J Cell Sci 2010*
• IRef Biogrid Interaction: MDM2 — TP63 (physical association, affinity chromatography technology) Calabrò et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MDM2 — TP63 (direct interaction, pull down) Zdzalik et al., Cell cycle (Georgetown, Tex.) 2010*