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IL2 — TNFSF9

Text-mined interactions from Literome

Gramaglia et al., Eur J Immunol 2000 : 4-1BBL alone, and to a greater extent with B7, also augmented IL-2 secretion resting antigen experienced CD4 cells, as typified by T helper clones, whereas short-term effector cells showed similar levels of proliferation and cytokine secretion regardless of whether 4-1BB was engaged
Cannons et al., J Immunol 2001 : We found that CD8 T cells produced IL-2 and IFN-gamma in a 4-1BBL dependent manner, whereas under the same conditions the CD4 T cells produced IL-2 and IL-4
Wen et al., J Immunol 2002 : CD28 and 4-1BB were found to synergize in the induction of IL-2 by human T cells, and CTLA-Ig partially blocked 4-1BBL dependent IL-2 production
Lee et al., Immunology 2008 : We found that de novo expression or overexpression of OX40L, 4-1BBL and IL-12p70 on activated B cells synergistically enhanced proliferation as well as IL-2 and interferon-gamma production by CD8+ T cells
DeBenedette et al., J Exp Med 1995 (Lymphoma, B-Cell) : These data suggest that 4-1BB ligand plays an important role in costimulation of IL-2 production and proliferation by T cells
Saoulli et al., J Exp Med 1998 : When coimmobilized on plastic with anti-CD3, soluble 4-1BBL induces interleukin (IL)-2 production by resting CD28+ or CD28- T cells, indicating that 4-1BBL can function independently of other cell surface molecules, including CD28, in costimulation of resting T cell activation ... In support of a functional role for TRAF2 in 4-1BB signaling, we find that resting T cells isolated from TRAF2-deficient mice or from mice expressing a dominant negative form of TRAF2 fail to augment IL-2 production in response to soluble 4-1BBL