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CTNNB1 — MUC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → Complex of CTNNB1-MUC1 (increases, CTNNB1/MUC1 Activity) Huang et al., Cancer Biol Ther 2003*
  Evidence: The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta-catenin, and colocalizes with beta-catenin in the nucleus;
• OpenBEL Selventa BEL large corpus: CTNNB1 → MUC1 (increases, MUC1 Activity) Huang et al., Cancer Biol Ther 2003*
  Evidence: The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta-catenin, and colocalizes with beta-catenin in the nucleus;

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Yamamoto et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2001*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (direct interaction, pull down) Li et al., J Biol Chem 2001*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (direct interaction, pull down) Li et al., J Biol Chem 2001*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2001*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Ren et al., J Biol Chem 2002*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Schroeder et al., Oncogene 2003*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (physical association, affinity chromatography technology) Li et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (direct interaction, pull down) Li et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (direct interaction, pull down) Li et al., Cancer Biol Ther 2003*
• IRef Biogrid Interaction: CTNNB1 — MUC1 (direct interaction, pull down) Yamamoto et al., J Biol Chem 1997*
• IRef Hprd Interaction: CTNNB1 — MUC1 (in vitro) Li et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*, Ren et al., J Biol Chem 2002*, Li et al., Cancer Biol Ther 2003*, Schroeder et al., Oncogene 2004*, Yamamoto et al., J Biol Chem 1997*
• IRef Hprd Interaction: CTNNB1 — MUC1 (in vivo) Li et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*, Ren et al., J Biol Chem 2002*, Li et al., Cancer Biol Ther 2003*, Schroeder et al., Oncogene 2004*, Yamamoto et al., J Biol Chem 1997*
• IRef Innatedb Interaction: Complex of CTNNB1-MUC1-MUC1 (unknown, -) Molock et al., Biochem Biophys Res Commun 2006*
• IRef Innatedb Interaction: MUC1 — CTNNB1 (unknown, -) Lillehoj et al., Biochim Biophys Acta 2007*
• IRef Innatedb Interaction: MUC1 — CTNNB1 (unknown, -) Li et al., Biochem Biophys Res Commun 2004*
• IRef Ophid Interaction: MUC1 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MUC1 — CTNNB1 (aggregation, confirmational text mining) Li et al., J Biol Chem 2001*

Text-mined interactions from Literome

Li et al., J Biol Chem 2001 : Moreover and in contrast to GSK3 beta, in vitro and in vivo studies demonstrate that c-Src mediated phosphorylation of MUC1 increases binding of MUC1 and beta-catenin
Li et al., J Biol Chem 2001 : The MUC1 cytoplasmic domain interacts with the c-Src tyrosine kinase and thereby increases binding of MUC1 and beta-catenin
Yuan et al., Biochem Biophys Res Commun 2007 : Downregulation of MUC1 expression also induced beta-catenin relocation from the nucleus to the cytoplasm, increased E-cadherin/beta-catenin complex formation and E-cadherin membrane localization in PANC1 cells
Poh et al., Cancer Res 2009 : Lack of Muc1 regulated beta-catenin stability results in aberrant expansion of CD11b+Gr1+ myeloid derived suppressor cells from the bone marrow ... MUC1 is a tumor associated mucin and its cytoplasmic tail ( MUC1-CT ) can regulate beta-catenin to promote oncogenesis ... Given the importance of beta-catenin in hematopoiesis, we hypothesized that the MUC1 regulation of beta-catenin is important for MDSC development
Li et al., Mol Cell Biol 1998 (Breast Neoplasms) : GSK3beta mediated phosphorylation of MUC1 had no apparent effect on beta-catenin levels or the transcriptional coactivation function of beta-catenin