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PTGS2 — SPP1

Text-mined interactions from Literome

Goppelt-Struebe et al., Kidney Int 2000 : The time pattern of Cox-2 and OPN expression suggested that Cox-2 might play a role in OPN induction
Jain et al., Cancer Res 2006 (Disease Progression...) : Here, we report that osteopontin , a small integrin binding ligand N-linked glycoprotein family of calcified extracellular matrix associated protein, regulates prostate tumor growth by regulating the expression of cyclooxygenase-2 (COX-2) ... We have revealed that suppression of osteopontin induced COX-2 expression by the nonsteroidal anti-inflammatory drug celecoxib or blocking the EP2 receptor by its blocking antibody resulted in significant inhibition of cell motility and tumor growth and angiogenesis
Yao et al., J Exp Clin Cancer Res 2011 (Neoplasms, Experimental...) : The results of RT-PCR and western blot showed that down-regulation of COX-2 might inhibit VEGF, Flt-1, Flk-1/KDR, angiopoietin-1, tie-2, MMP2 and OPN