Benhayon et al., Brain Res Mol Brain Res 2003
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Here we compare the roles of ApoER2 and VLDLR in Reelin signaling ... These findings demonstrate that ApoER2 and VLDLR are essential for Reelin signaling and that no other receptor molecules can compensate for their role in mediating tyrosine phosphorylation of Dab1
Beffert et al., J Neurosci 2006
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Using primary neuronal cultures stimulated with recombinant Reelin, we find that normal Reelin signaling requires the wild-type NFDNPVY sequence and likely the interaction of Apoer2 with Dab1
Duit et al., J Biol Chem 2010
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Binding of Reelin to ApoER2, a resident of rafts, leads to the production of specific receptor fragments with specific functions of their own and to degradation of ApoER2 via lysosomes
Chen et al., J Biol Chem 2012
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Taken together, these data support a model in which activation of VLDLR and apoER2 by reelin and apoE induces ABCA1 expression and cholesterol efflux via a Dab1-PI3K-PKC?-Sp1 signaling cascade