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LIMK1 — RAC3

Text-mined interactions from Literome

Nishita et al., Mol Cell Biol 2002 : Expression of dominant negative Rac ( DN-Rac ), but not DN-Rho or DN-Cdc42, blocked SDF-1alpha induced activation of LIMK1 , which means that SDF-1alpha induced LIMK1 activation is mediated by Rac but not by Rho or Cdc42
Thirone et al., Am J Physiol Cell Physiol 2009 : Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Huang et al., Biochem Biophys Res Commun 2012 (Vitreoretinopathy, Proliferative) : Vitreous treatment also enhanced the phosphorylation of LIMK1 and cofilin and the Rac inhibitor blocked this effect
Yang et al., Nature 1998 : Furthermore, insulin and an active form of Rac increase the activity of LIMK-1