Higashida et al., J Neurosurg 2011
(Brain Edema...) :
Anti-AQP-4 antibody, minocycline ( an inhibitor of MMP-9 ), or 2-methoxyestradiol ( 2ME2 , an inhibitor of HIF-1a ), was administered intravenously 30 minutes after injury
Shenaq et al., J Neurol Sci 2012
(Brain Damage, Chronic...) :
Animals in each treatment group were administered intravenous anti-AQP4 or -AQP9 antibodies or 2-Methoxyestradiol ( 2ME2 , an inhibitor of HIF-1a ) 30 min after injury
Zhou et al., PloS one 2012
(Inflammation...) :
2ME2 effectively inhibited HIF-1a and VEGF expression and attenuated the inflammatory responses