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MDM2 — PSMD10

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MDM2 — PSMD10 (coimmunoprecipitation) Higashitsuji et al., Cancer Cell 2005*
• IRef Bind_translation Interaction: MDM2 — PSMD10 (affinity chromatography technology) Higashitsuji et al., Cancer Cell 2005*
• IRef Biogrid Interaction: MDM2 — PSMD10 (direct interaction, pull down) Qiu et al., Oncogene 2008*
• IRef Biogrid Interaction: MDM2 — PSMD10 (physical association, affinity chromatography technology) Qiu et al., Oncogene 2008*
• IRef Biogrid Interaction: MDM2 — PSMD10 (physical association, affinity chromatography technology) Higashitsuji et al., Cancer Cell 2005*
• IRef Biogrid Interaction: MDM2 — PSMD10 (direct interaction, pull down) Higashitsuji et al., Cancer Cell 2005*
• IRef Biogrid Interaction: MDM2 — PSMD10 (direct interaction, pull down) Higashitsuji et al., Biochem Biophys Res Commun 2007*
• IRef Hprd Interaction: PSMD10 — MDM2 (in vitro) Higashitsuji et al., Cancer Cell 2005*
• IRef Hprd Interaction: PSMD10 — MDM2 (in vivo) Higashitsuji et al., Cancer Cell 2005*
• IRef Hprd Interaction: Complex of 36 proteins (in vivo) Maguire et al., Cancer Res 2008
• IRef Hprd Interaction: Complex of MDM4-MDM2-DHFR-MTBP-PSMD10-RB1 (in vivo) Maguire et al., Cancer Res 2008

Text-mined interactions from Literome

Higashitsuji et al., Cell cycle (Georgetown, Tex.) 2005 : Gankyrin increases activities of CDK4 and MDM2 , and facilitates targeting of polyubiquitylated proteins to the 26S proteasome
Dai et al., J Biol Chem 2006 : We further show that L11 inhibited 26 S proteasome mediated degradation of ubiquitinated MDM2 in vitro and consistently prolonged the half-life of MDM2 in cells
Kuo et al., Biochem Pharmacol 2012 (Carcinoma, Hepatocellular...) : Gankyrin , a positive regulator of the E3 ubiquitin ligase MDM2 , was found to be upregulated following HURP expression, and gankyrin knockdown decreased the HURP mediated downregulation of p53