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MAP2K4 — MAPK6
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Fanning et al., J Biol Chem 2003
(MAP Kinase Signaling System...) :
Mechanical compression induced a phased phosphorylation of ERK consisting of a rapid induction of ERK1/2 phosphorylation at 10 min, a rapid decay, and a sustained level of ERK2 phosphorylation that persisted for at least 24 h. Mechanical compression also
induced the phosphorylation of p38
MAPK in strictly a transient fashion, with maximal phosphorylation occurring at 10 min. Mechanical compression stimulated
SEK1 phosphorylation, with a maximum at the relatively delayed time point of 1 h and with a higher amplitude than ERK1/2 and p38 MAPK phosphorylation
Lin et al., Science 1995
:
JNKK also
activated another
MAPK , p38 ( Mpk2 ; the mammalian homolog of HOG1 from yeast ), whose activity is regulated similarly to that of the JNKs
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Guan et al., J Biol Chem 1998
:
We also found that overexpression of the constitutively active form of
SEK1 ( SEK1-ED )
increases both p38
MAPK and JNK/SAPK phosphorylation, and increases PGE2 production and Cox-2 expression
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner
Ganiatsas et al., Proc Natl Acad Sci U S A 1998
:
SEK1 (
MKK4/JNKK ) is a
mitogen activated protein kinase activator that has been shown to participate in vitro in two stress activated cascades terminating with the SAPK and p38 kinases