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CCL2 — MMP9

Text-mined interactions from Literome

Robinson et al., Eur J Immunol 2002 : Chemokines increased TNF-alpha mRNA levels and protein release in monocytes and THP-1 cells, and neutralizing anti-TNF-alpha antibodies inhibited CCL2 induced MMP-9 release
Zhao et al., Biochem Biophys Res Commun 2007 (Lyme Disease) : The secreted MCP-1 may affect the production of MMP-9 in fibroblasts and/or macrophages
Tieu et al., J Clin Invest 2009 (Aneurysm, Dissecting...) : In vitro, coculture of monocytes and aortic adventitial fibroblasts produced MCP-1- and IL-6 enriched conditioned medium that promoted differentiation of monocytes into macrophages, induced CD14 and CD11b upregulation, and induced MCP-1 and MMP-9 expression
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : MMP inhibitors, such as doxycycline, minocycline, and batimastat, significantly reduced the cerebral infarct size, and the expressions of monocyte chemotactic protein-1 (MCP-1) , tumor necrosis factor-a (TNF-a), and indoleamine 2,3-dioxygenase (IDO)
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Abdulkhalek et al., Cell Signal 2013 (Inflammation) : Tamiflu, specific MMP-9 inhibitor, neuromedin B receptor specific antagonist BIM23127, and the selective inhibitor of whole heterotrimeric G-protein complex BIM-46174 significantly block nucleic acid induced TLR-7 and -9 MyD88 recruitment, NF-?B activation and proinflammatory TNFa and MCP-1 cytokine responses