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CXCL10 — IL4
Text-mined interactions from Literome
Albanesi et al., J Immunol 2000
(Calcium Signaling...) :
IL-4 , but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and
increased the levels of
IP-10 and Mig in keratinocyte supernatants
Giustizieri et al., J Allergy Clin Immunol 2001
(Dermatitis, Atopic...) :
IL-4 weakly
induced IP-10 , RANTES, and IL-8 but not MCP-1
Kanda et al., Clin Exp Allergy 2002
(Dermatitis, Atopic...) :
MF
induced IL-4 and macrophage derived chemokine (MDC) secretion in AD patients, while induced IFN-gamma and
interferon-inducible protein of 10 kDa (IP-10) secretion in PV patients, however, did not induce either secretion in normal subjects
Kakinuma et al., Cytokine 2002
:
Furthermore, the
effects of
IL-4 on TARC and
IP-10 production in these cells were detected in a dose dependent manner
Wright et al., J Clin Immunol 2003
(Osteomyelitis...) :
We investigated the potential down-regulators of chemokine secretion
IL-4 , IL-10, IL-13, dexamethasone, and PGE2, IL-10 and IL-13 down-regulate M. tuberculosis
induced IL-8,
IP-10 , RANTES, and MCP-1 secretion from MG-63 cells by between 48 and 94 % ( P < 0.05 ) but do not inhibit chemokine gene transcription
Thomas et al., J Immunol 2004
(Bronchial Hyperreactivity) :
In lymphocytes restimulated with CXCL9 and allergen in vitro,
CXCL9 down-regulated
IL-4 expression and up-regulated IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Wright et al., Microbes Infect 2004
:
IL-10 and IL-13 reduced S. aureus induced osteoblast C-X-C chemokine secretion, whereas
IL-4 decreased CXCL8 secretion 2.5-fold and
increased CXCL10 secretion 3-fold ( all P < 0.05 )
Herder et al., Int J Obes Relat Metab Disord 2007
:
In cultures of human mature adipocytes and in vitro differentiated adipocytes,
IP-10 expression under basal conditions and in the
presence of IFNgamma, lipopolysaccharide (LPS) or
interleukin (IL)-4 was characterized by reverse transcriptase-polymerase chain reaction, Luminex technology and immunofluorescence ... In in vitro differentiated adipocytes from s.c. and mammary depots and in mature s.c. adipocytes, IP-10 secretion was strongly upregulated by IFNgamma, whereas LPS or
IL-4 did not
affect IP-10 expression in s.c. mature adipocytes
Méndez-Samperio et al., Mediators Inflamm 2006
:
We found that, although M. bovis BCG induced gene expression of CXCL-8 and CXCL-10 in M. bovis BCG infected human epithelial cells,
CXCL-8 mRNA level was significantly
reduced by
IL-4 , whereas no significant effect of IL-4 was observed on CXCL10 mRNA level ... Furthermore, we found a similar
effect of
IL-4 on M. bovis BCG induced
CXCL-8 and CXCL-10 secretion by using other human epithelial A549 cell line
Huang et al., Am J Physiol Lung Cell Mol Physiol 2007
:
IL-4 stimulates the expression of
CXCL-8 , E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells
Hosokawa et al., J Periodontal Res 2009
(Periodontitis) :
However,
interleukin-4 and interleukin-13
inhibited CXCL10 production by interferon-gamma stimulated or tumor necrosis factor-alpha-stimulated-human gingival fibroblasts ... However,
interleukin-4 and interleukin-13
inhibited CXCL10 production by interferon-gamma stimulated or tumor necrosis factor-alpha-stimulated-human gingival fibroblasts ... On the other hand,
interleukin-17A and interleukin-22 enhanced CXCL10 production by human gingival fibroblasts treated with interferon-gamma and
inhibited CXCL10 production by tumor necrosis factor-alpha stimulated human gingival fibroblasts
Tousi et al., Neurosci Lett 2012
(Parkinson Disease) :
a-Synuclein potentiates
interleukin-1ß induced
CXCL10 expression in human A172 astrocytoma cells
Deng et al., J Immunol 1994
:
Mechanisms of
IL-4 mediated suppression of
IP-10 gene expression in murine macrophages ... The mechanisms involved in negative
regulation of IFN-gamma induced
IP-10 mRNA expression by
IL-4 have been examined in an immortalized murine macrophage cell line ( ANA-1 ) ... Together, these findings demonstrate that
IL-4 inhibits
IP-10 mRNA production in murine macrophages by suppressing the formation of new transcripts
Gangur et al., FASEB J 1998
:
We examined the
effect of recombinant human
IP-10 ( rhIP-10 ) on human interferon gamma (IFN-gamma) and
interleukin 4 (IL-4) production by fresh peripheral blood mononuclear cells