Shah et al., Mol Endocrinol 2005
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In contrast, LPA induced phosphorylation of Shc and ERK1/2 in clonal hepatocytes ( C9 cells ) was primarily mediated through MMP dependent transactivation of the EGF-R
Kranenburg et al., EMBO J 1997
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Furthermore, LPA induced tyrosine phosphorylation of Shc is PTX-insensitive and Ca2+ dependent in COS cells, but undetectable in Rat-1 cells ... Expression of dominant negative Src or Shc does not affect MAP kinase activation by LPA Luttrell et al., J Biol Chem 1997
:
In contrast, only LPA and thrombin receptors significantly stimulate Shc tyrosine phosphorylation and Shc-Grb2 complex formation