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IRS1 — SHC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS1 (IRS1) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS1 (IRS1) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHC (SHC1) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → GRB2 (GRB2) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHIP (INPP5D) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: SHC (SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → None (modification, activates) Mahadev et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: IRS1 (IRS1) → SHC (SHC1) (modification, collaborate) Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: IRS1 (IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: SHC (SHC1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: GRB2 (GRB2) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) → Insulin Receptor/Insulin complex (INSR-INS) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → IRS1 (IRS1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC (SHC1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: IRS1 (IRS1) → SHC (SHC1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → IRS1 (IRS1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC (SHC1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: IRS1 (IRS1) → SHC (SHC1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
  Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → SOS1 (SOS1) (modification, collaborate) Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: SOS1 (SOS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GTP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, activates)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GDP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• WikiPathways Insulin Signaling: SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 → Complex of IRS1-PIK3CA (activation)
• WikiPathways DNA Damage Response (only ATM dependent): IRS1 → SHC1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: SHC1 — IRS1 (two hybrid) Kasus-Jacobi et al., J Biol Chem 1997*
• IRef Bind_translation Interaction: SHC1 — IRS1 (affinity chromatography technology) Kasus-Jacobi et al., J Biol Chem 1997*
• IRef Biogrid Interaction: IRS1 — SHC1 (direct interaction, pull down) Wolf et al., J Biol Chem 1995*
• IRef Hprd Interaction: SHC1 — IRS1 (in vitro) Wolf et al., J Biol Chem 1995*
• IRef Ophid Interaction: SHC1 — IRS1 (aggregation, confirmational text mining) Wolf et al., J Biol Chem 1995*
• IRef Ophid Interaction: SHC1 — IRS1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tanaka et al., J Clin Invest 1996 (Carcinoma, Hepatocellular...) : Expression of a carboxy-terminal truncated IRS-1 molecule containing the pleckstrin homology and phosphotyrosine binding domains associates with the insulin receptor and prevents tyrosyl phosphorylation of endogenous IRS-1 and Shc proteins
Ishihara et al., J Biol Chem 1997 : Likewise, reduction of endogenous Shc expression by antisense Shc mRNA resulted in increased insulin stimulation of IRS-1 phosphorylation
Sharma et al., Mol Cell Biol 1997 : Thus, interference with the IRS-1-IR interaction inhibits insulin stimulated IRS-1 and Shc phosphorylation, PI 3-K enzymatic activity, p70s6k activation, MAPK phosphorylation and cell cycle progression