Gene interactions and pathways from curated databases and text-mining

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BIRC3 — CASP10

Text-mined interactions from Literome

Partheniou et al., Biochem Biophys Res Commun 2001 (Leukemia) : In contrast, there was a caspase dependent cleavage of XIAP, but not c-IAP1 , during treatment with TNFalpha for 7 days
Mica et al., J Am Coll Surg 2004 (Sepsis) : Endotoxin reduces CD95 induced neutrophil apoptosis by cIAP-2 mediated caspase-3 degradation
Levkovitch-Verbin et al., Invest Ophthalmol Vis Sci 2006 (Disease Models, Animal...) : Proapoptotic genes from the p-53 pathway ( Ei24 and Gadd45a ), Cdk2 and the prosurvival gene IAP-1 ( a caspase inhibitor ) were simultaneously and significantly upregulated early after ONT, returning to baseline at 2 weeks
Igaki et al., Biochem Biophys Res Commun 2007 : DmHtrA2 specifically cleaves Drosophila inhibitor-of-apoptosis protein 1 ( DIAP1 ), a cellular caspase inhibitor , and induces cell death both in vitro and in vivo as potent as other fly cell death proteins
Das et al., Cancer 2007 (Glioblastoma) : Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and activation of calpain, caspase-9 , and caspase-3
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Karmakar et al., Neuroscience 2009 (Body Weight...) : Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing ( BIRC ) proteins including BIRC-2 and BIRC-3, and activation of caspase-3 and apoptosis inducing factor ( AIF )