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RAC3 — SOS1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
RAC3
→
SOS1
(reaction)
Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998
Text-mined interactions from Literome
Innocenti et al., J Cell Biol 2002
:
Thus, the involvement of
Sos-1 at two distinct and differentially regulated steps of the signaling cascade
allows for coordinated activation of Ras and
Rac and different duration of their signaling within the cell
Sini et al., Nat Cell Biol 2004
:
Abl dependent tyrosine phosphorylation of
Sos-1 mediates growth-factor induced
Rac activation
Silver et al., Genesis 2004
:
These alleles provide new tools for future investigations of
SOS mediated activation of both RAS and
RAC and how these dual roles are coordinated and coregulated during development