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AKT2 — TRIM72
Text-mined interactions from Literome
Lee et al., Cell Death Differ 2010
:
Because TRIM72 promoter analysis shows that two proximal E-boxes in TRIM72 promoter were essential for MyoD- and
Akt dependent
TRIM72 transcription, we can conclude that TRIM72 is a novel antagonist of IRS-1, and is essential as a negative regulator of IGF induced muscle differentiation
Ham et al., Exp Cell Res 2013
(Cardiomegaly...) :
TRIM72 specifically
regulated IGF-1 dependent
AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes