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SOX17 — WNT3

Text-mined interactions from Literome

Fu et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : These findings indicate that silencing of Sox17 due to promoter hypermethylation is a frequent event and may contribute to aberrant activation of Wnt signaling in breast cancer
Du et al., Gastroenterology 2009 (Cell Transformation, Neoplastic...) : Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer ... Sox17 was induced in K19-Wnt1/C2mE mouse gastric tumors and K19-Wnt1 preneoplastic lesions, where Wnt/beta-catenin signaling was activated ... Consistently, Wnt activation induced Sox17 expression in gastric cancer cells ... However, Sox17 is induced by Wnt activation in the early stage of gastrointestinal tumorigenesis, and Sox17 is down-regulated by methylation during malignant progression
Kormish et al., Dev Dyn 2010 (Neoplasms) : In some contexts, Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine-tune cellular responses to beta-catenin/TCF activity
Wang et al., J Biol Chem 2013 (Breast Neoplasms...) : Consistently, SOX9 overexpression in BCa cell lines and transgenic SOX9 expression in breast epithelium caused increased LRP6 and TCF4 expression and Wnt/ß-catenin activation
Chen et al., Cancer Lett 2013 (Oligodendroglioma...) : These changes were associated with increased SFRP1, and reduced expression of Wnt-1 and Frizzled-1, -3 and -7 RNA, indicating that Sox17 induced a Hedgehog target, and regulated Wnt signaling at multiple levels