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IL1A — SAA1

Text-mined interactions from Literome

Heal et al., Mol Immunol 1999 : A best-fit peptide corresponding to this motif was synthesised and found to bind to IL-1beta as well as inhibit the response to IL-1 in two independent in vitro bioassays ( monitoring IL-1 dependent serum amyloid A synthesis and IL-1 dependent alkaline phosphatase activity, respectively )
Vallon et al., J Immunol 2001 (Arthritis, Rheumatoid...) : In the human experimental system, IL-1beta induced transcription of acute-phase SAA ( A-SSA ; encoded by SAA1/SAA2 ) in primary chondrocytes
Kumon et al., Scand J Immunol 2001 (Acute-Phase Reaction...) : Dexamethasone, but not IL-1 alone, upregulates acute-phase serum amyloid A gene expression and production by cultured human aortic smooth muscle cells
Sasaki et al., J Med Microbiol 2001 (Streptococcal Infections) : Furthermore, a reverse transcription-PCR assay revealed that SAA 10 microg/ml could induce mRNA accumulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 as well as iNOS
Thorn et al., Amyloid 2002 : The Saa1 and Saa2 promoters are strongly induced by IL-6, with synergistic upregulation of Saa2, but not of Saa1, by IL-1 or TNF
Ribeiro et al., Mediators Inflamm 2003 : In a previous study, we reported that SAA induces the release of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-8 from human blood neutrophils
Numerof et al., Cytokine 1992 : In this investigation, we examined the role of endogenous IL-1 in the synthesis of the hepatic acute phase protein serum amyloid A (SAA) during IL-2 treatment
Ganapathi et al., Biochem J 1992 (Carcinoma, Hepatocellular...) : Okadaic acid ( OA ), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose dependent manner ( 5-20 nM ) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1) , and of fibrinogen by IL-6 alone, in Hep 3B cells
Ganapathi et al., J Immunol 1991 (Carcinoma, Hepatocellular...) : Similar results were obtained for the effect of dexamethasone on the induction of SAA by IL-6 plus IL-1 alpha
Bevan et al., J Immunol 1991 (Carcinoma, Hepatocellular...) : The hepatoma cell line HuH-7 has recently been shown to synthesize serum amyloid A (SAA) in response to IL-1 ... Removal of IL-1 at 24 h rapidly reduced the SAA secreted over the next 24 h. Addition of IL-1Ra to the cells at this time was as effective as removal of IL-1 at inhibiting the subsequent secretion of SAA
Dowton et al., Pediatr Res 1991 (Acute-Phase Reaction) : Studies of immature hamsters after birth show that the responses of CRP and SAA genes to lipopolysaccharide, tumor necrosis factor, IL-1 , and IL-6 are reduced when compared with induction of mRNA accumulation for these acute phase reactants in adult animals
Yoshizaki et al., Yakugaku Zasshi 2009 (Autoimmune Diseases...) : The results, indicated that the IL-6 signal was essential though the activation of STAT3 for the induction and augmentation of CRP or SAA by the associated stimulation with TNF-alpha or IL-1
Yap et al., Biochim Biophys Acta 1991 : It inhibits also the stimulatory effect of IL-1 and IL-6 on the synthesis of CRP and SAA
Migita et al., Clin Exp Immunol 2010 (Arthritis, Rheumatoid) : These results indicate that SAA is a significant inducer of IL-23 and IL-1ß in RA synoviocytes and potentially activates the IL-23/IL-17 pathway in the RA synovium
Migita et al., Arthritis Res Ther 2012 (Gout) : Neither SAA nor MSU stimulation resulted in IL-1ß or interleukin-1a (IL-1a) secretions and pro-IL-1ß processing in synovial fibroblasts ... The effect of SAA on IL-1ß induction was impaired in cells by silencing NLRP3 using siRNA or treating with caspase-1 inhibitor
Jabaut et al., Free Radic Biol Med 2013 : In this study, we explore the impact of mitochondria dysfunction and ROS production on Nlrp3 inflammasome stimulation and IL-1ß secretion induced by serum amyloid A (SAA) in primary mouse peritoneal macrophages
Ramadori et al., J Exp Med 1985 (Inflammation) : In primary murine hepatocyte cultures, both the recombinant IL-1 and highly purified human IL-1 induced a dose- and time dependent, reversible increase in expression of the SAA and factor B genes, and a decrease in albumin gene expression
Neta et al., Lymphokine Res 1988 (Acute-Phase Reaction) : Therefore, IL 1 is a more effective inducer of fibrinogen and SAA in mice than is IL 6
Ghezzi et al., Lymphokine Res 1988 : Dexamethasone modulation of LPS, IL-1 , and TNF stimulated serum amyloid A synthesis in mice ... Exogenous IL-1 and TNF induce SAA synthesis in vivo and in vitro, while exogenous IL-6 is a far less potent stimulus of in vivo SAA gene expression ... However, DEX did not reduce, but rather potentiated, IL-1 and TNF stimulated SAA production, indicating that these monokines do not require macrophage products to mediate their in vivo SAA inducer activity
Sipe et al., Lymphokine Res 1987 : The time course of in vivo induction of SAA synthesis by IL-1 was found to vary according to dose, in that SAA concentration was maximal at 6 hours following lower doses of IL-1, but greater at 20 hours when higher ( greater than 500 ng ) doses were administered
Gabay et al., Clin Exp Immunol 1995 (Carcinoma, Hepatocellular) : In the hepatoma cell line, IL-1 beta and/or TNF-alpha had synergistic effects with IL-6 on the production of CRP and SAA
Conti et al., Immunol Invest 1995 (Carcinoma, Hepatocellular) : Synergistic activation of serum amyloid A (SAA) by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line
Kumon et al., Scand J Immunol 1997 : Regulation of extrahepatic apolipoprotein serum amyloid A ( ApoSAA ) gene expression by interleukin-1 alpha alone : synthesis and secretion of ApoSAA by cultured aortic smooth muscle cells
Ray et al., J Biol Chem 1999 : We demonstrate that SAA is synergistically induced in synovial cells by interleukin (IL)-1 and IL-6 that are present at significantly high level in the synovial fluid of arthritis patients ... Mutation of these sequences abolishes SAA promoter response to IL-1 and IL-6