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IL12B — TLR5

Text-mined interactions from Literome

Del Rio et al., J Immunol 2004 : Although we identify TLR2 as the receptor triggering CCL2 production, parasite induced IL-12 release did not involve this TLR
Gautier et al., J Exp Med 2005 : Dendritic cells ( DC ) produce interleukin-12 (IL-12) in response to Toll-like receptor ( TLR ) activation
Yarovinsky et al., Science 2005 (Toxoplasmosis, Animal) : Moreover, TLR11 is required in vivo for parasite induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens
Lehner et al., Immunol Lett 2005 : However, IL-12p70 production in response to Toll-like receptor ( TLR ) stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions, nanogram quantities of IL-12 were produced
Kuwata et al., Immunity 2006 (Colitis...) : IkappaBNS-deficient macrophages and dendritic cells show increased TLR mediated expression of genes such as IL-6 and IL-12p40 , which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Agrawal et al., J Immunol 2006 (Encephalomyelitis, Autoimmune, Experimental...) : Consistent with this observation, dendritic cells from ERK1 ( -/- ) mice show enhanced IL-12p70 and reduced IL-10 secretion in response to TLR stimulation
Bekeredjian-Ding et al., J Immunol 2006 : T cell independent, TLR induced IL-12p70 production in primary human monocytes
Karrasch et al., J Immunol 2007 (Colitis...) : IL-10-/- ; MyD88-/- mice were used to assess E. faecalis/E. coli induced TLR dependent signaling and IL-23 gene expression
Polumuri et al., J Immunol 2007 : Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages ... Because PI3K deficiency has been associated with increased IL-12, we hypothesized that PI3K was central to the anti-inflammatory effect of FcgammaR ligation on TLR induced IL-12 ... This increase was blocked by PI3K inhibitors, wortmannin or LY294002, as was the effect of FcgammaR ligation on TLR induced IL-12 and IL-10
Sá-Nunes et al., J Immunol 2007 : Saliva at remarkably diluted concentrations ( < 1/2000 ) promotes a dose dependent inhibition of IL-12 and TNF-alpha production induced by all TLR ligands used
Waggoner et al., J Leukoc Biol 2007 : Herein, ligation of gC1qR on human monocyte derived DCs ( MDDCs ) with HCV core or anti-gC1qR agonist antibody was shown to inhibit TLR induced IL-12 production but not the production of other TLR stimulated cytokines
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and IFN-gamma by B cells
van Beelen et al., Immunity 2007 (Bacterial Infections...) : MDP enhanced obligate bacterial Toll-like receptor ( TLR ) agonist induction of IL-23 and IL-1, which promoted IL-17 expression in T cells
Siracusa et al., J Immunol 2008 : Exposure of bone marrow derived dendritic cells to E2 also enhanced production of IL-12 in response to the TLR ligands, CpG and LPS
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls
Hickey et al., J Leukoc Biol 2008 : Adenylate cycalse toxin of Bordetella pertussis inhibits TLR induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Behrens et al., J Immunol 2008 : A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses TLR induced TNF-alpha and IL-12 production and inhibits effective Ag presentation ... TLR induced TNF-alpha and IL-12 production by bone marrow derived DCs occurs heterogeneously, with apoptotic cells inhibiting only certain populations depending on the TLR agonist
Bode et al., J Immunol 2009 : Kinetic of RelA activation controls magnitude of TLR mediated IL-12p40 induction ... TLR ligands induce IL-12 to differing extents
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in response to TLR ligands
Renneson et al., Eur J Immunol 2009 : Neonatal myeloid DC were shown to be deficient in IFN-beta and IL-12 synthesis in response to TLR triggering
Kollmann et al., J Immunol 2009 : In response to most TLR ligands, neonatal innate immune cells, including monocytes and conventional and plasmacytoid dendritic cells produced less IL-12p70 and IFN-alpha ( and consequently induced less IFN-gamma ), moderately less TNF-alpha, but as much or even more IL-1beta, IL-6, IL-23, and IL-10 than adult cells
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma, IL-12 and/or TNF-alpha secretion
Zhou et al., J Leukoc Biol 2010 : Protein tyrosine phosphatase SHP-1 positively regulates TLR induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase ... Bone marrow derived macrophages ( BMDMs ) lacking significant SHP-1 activity display a profound defect in IL-12p40 synthesis in response to lipopolysaccharide, peptidoglycan, and synthetic TLR ligands, while producing normal amounts of other proinflammatory cytokines, such as TNFalpha and IL-6
Hayashi et al., Immunology 2010 : In the present study, we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on IL-12 and IL-23 production in response to Toll-like receptor ( TLR ) stimulation ... In the present study, we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on IL-12 and IL-23 production in response to Toll-like receptor ( TLR ) stimulation
Kucera et al., J Mol Biol 2010 : Substitution of the acidic loop in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not affect TLR11 dependent IL-12 secretion, while substitution with the acidic loop from Plasmodium falciparum results in reduced but significant IL-12 secretion
Pifer et al., J Biol Chem 2011 (Toxoplasmosis, Animal) : A deficiency in functional UNC93B1 protein abolished TLR11 dependent IL-12 secretion by dendritic cells, attenuated Th1 responses against T. gondii, and dramatically enhanced susceptibility to the parasite
Okazaki et al., J Biochem 2011 : C5a controls TLR induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase ... Mouse macrophages produce IL-12 and IL-10 in response to TLR ligands such as LPS, CpG, Poly I:C and Malp2 ... The TLR induced IL-12 production was decreased, while that of IL-10 was increased by concurrent stimulation with a complement fragment C5a
Zhang et al., J Immunol 2011 (Hepatitis C, Chronic) : PD-1 and SOCS-1 were found to associate by coimmunoprecipitation studies, and blocking PD-1 or silencing SOCS-1 in M/M ( F ) led to activation of STAT-1 during TLR stimulated IL-12 production
Zhang et al., J Leukoc Biol 2012 : Blocking Tim-3 signaling or silencing Tim-3 expression led to a significant increase in TLR mediated IL-12 production, as well as a decrease in activation induced up-regulation of the immunoinhibitor, PD-1 ; TNF-a production was not altered significantly, but IL-10 production was increased
Belderbos et al., Pediatr Allergy Immunol 2012 (Hypersensitivity) : Of innate immune variables, TLR3 mediated IL-12p70 production was highly associated with environmental exposures ( pets, breastfeeding and mode of delivery ), whereas TLR9 mediated cytokine responses were not associated with any environmental factor
Kwok et al., Arthritis Res Ther 2012 (Sjogren's Syndrome) : The stimulation of TLR2, TLR4 and TLR6 additively induced the production of IL-17 and IL-23 from the PBMCs of pSS patients especially in the presence of TLR2 stimulation
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a, IFN-a, IL-6, and IL-12 were measured by multicolor flow cytometry
Ichikawa et al., PloS one 2012 : Here, we examine the role of toll-like receptors ( TLR 's ) and reactive oxygen species ( ROS ) in IL-12 production by LAB stimulated peritoneal macrophages ... Our results indicate that a TLR is not necessary for IL-12 induction by LAB, whilst the universal adaptor protein, MyD88, is essential
Zaal et al., Immunobiology 2013 : While C5a indeed enhanced cytokine production of immature DCs, the addition of C5a inhibited production of IL-12, IL-23 and TNFa induced by various TLR ligands such as LPS, R848 and Pam ( 3 ) CSK ( 4 ) ... While C5a indeed enhanced cytokine production of immature DCs, the addition of C5a inhibited production of IL-12 , IL-23 and TNFa induced by various TLR ligands such as LPS, R848 and Pam ( 3 ) CSK ( 4 )
Liu et al., Eur J Immunol 2012 : Type I and III interferons enhance IL-10R expression on human monocytes and macrophages, resulting in IL-10 mediated suppression of TLR induced IL-12 ... This indicates that IFN-a increased the sensitivity of monocytes to IL-10, and as a result, TLR induced IL-12p70 by IFN pretreated cells was suppressed ... In summary, we demonstrate that one of the consequences of priming human APCs with IFN is to promote the cells ' sensitivity to IL-10, which leads to the inhibition of TLR induced IL-12p70 production
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF, and up-regulation of CD40 on the surface
Gentle et al., J Immunol 2012 : We demonstrate that concurrent Notch and TLR stimulation results in a unique cytokine profile in mouse bone-marrow derived DCs characterized by enhanced IL-10 and IL-2, and reduced IL-12 expression compared with TLR ligation alone
McBerry et al., J Immunol 2012 (Disease Models, Animal...) : p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production ... p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6, TNF-a, and IL-12 in BMDCs in response to A. baumannii
Miyazawa et al., J Biochem 2012 : However, Okazaki et al. ( C5a controls TLR induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase ... 2011 ; 149 : 265-274 ) recently indicated that PI3K activated downstream of C5a anaphylatoxin does not affect the induction of IL-12 by TLR , although C5a efficiently inhibits the induction, in macrophages ... PI3K is thus a context dependent regulator of TLR mediated IL-12 production
Perugorria et al., Hepatology 2013 (Liver Cirrhosis...) : KCs lacking Tpl2 display defects with TLR induction of cytokines interleukin (IL)-1ß, IL-10, and IL-23
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : TLR12 dependent induction of IL-12 and IFN-a in pDCs led to production of IFN-? by NK cells
Ferrante et al., Inflammation 2013 : Adenosine signaling suppresses the TLR dependent expression of TNF-a, IL-12 , IFN-?, and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10
Koopman et al., Clin Exp Immunol 2013 : Both in humans and rhesus macaques, TLR-4 stimulation induced IL-12p40 expression in mDC and monocytes, but not in pDC
Compté et al., PloS one 2013 : The aim of our study was to define the relative contribution of age and clinical status on TLR induced interleukin (IL)-12p70 and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens, respectively ... The aim of our study was to define the relative contribution of age and clinical status on TLR induced interleukin (IL)-12p70 and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens, respectively
Callahan et al., J Immunol 2013 (Disease Susceptibility...) : ABIN-1-deficient DCs display exaggerated NF-?B and MAPK signaling and produce more IL-23 than do normal cells in response to TLR ligands
Römmler et al., J Immunol 2013 : Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs
Ma et al., PloS one 2013 : Current models imply that Tim-3 expression on M/MO can deliver negative signaling to TLR mediated IL-12 expression through trans association with its ligand Galectin-9 (Gal-9) presented by other cells ... In this study, our data suggest that Tim-3 and IL-12/IL-23 gene transcriptions are regulated by enhanced or silenced Gal-9 expression within monocytes through synergizing with TLR signaling ... In this study, our data suggest that Tim-3 and IL-12/IL-23 gene transcriptions are regulated by enhanced or silenced Gal-9 expression within monocytes through synergizing with TLR signaling