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FAS — IL12B

Text-mined interactions from Literome

Lafleur et al., Cancer Res 2001 (Bone Neoplasms...) : Infection of the LM6 cells with an adenoviral vector containing the murine interleukin (IL)-12 gene ( AD : mIL-12 ) or treatment with recombinant murine IL-12 resulted in a dose dependent up-regulation of FAS : The up-regulation of Fas by IL-12 was also demonstrated in human etoposide-resistant MDA-MB-231 breast cancer cells
Gumperz et al., J Exp Med 2002 : In contrast, CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines, up-regulated perforin in response to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or IL-12 , and could be induced to express CD95L
Kitaura et al., J Immunol 2002 : Apoptosis of the adherent cells was markedly inhibited by anti-Fas ligand (FasL) Ab. RT-PCR and FACS analyses revealed that TNF-alpha up-regulated Fas transcription to lead to Fas expression on the surfaces of the adherent cells, whereas IL-12 could not induce Fas on the cells
Perl et al., Am J Pathol 2005 (Disease Models, Animal...) : Only Fas-siRNA markedly diminished lung tissue tumor necrosis factor-alpha, IL-6, IL-10, interferon-gamma, IL-12 , and caspase-3 activity
Kitaura et al., Immunol Lett 2006 : We previously reported that the proinflammatory cytokine IL-12 induced apoptosis in TNF-alpha mediated osteoclastogenesis in mouse bone marrow culture through an interaction of Fas and Fas ligand (FasL)
Yoshimatsu et al., Bone 2009 : These results suggest that IL-12 inhibits TNF-alpha mediated osteoclastogenesis and induces apoptotic changes through an interaction between TNF-alpha induced Fas and IL-12 induced FasL, in vivo, via a T cell independent mechanism
Kondo et al., Immunology 2009 (Myositis) : Taken together, these results suggest that proinflammatory cytokines enhance Fas mediated apoptosis of muscle cells, and that the Fas/FasL interaction between invading dendritic cells and CD4 ( + ) T cells induces local production of IL-23 and proinflammatory cytokines, which can promote the proliferation of Th17 cells and enhance Fas mediated apoptosis of muscle cells, respectively
Hu et al., Mol Med Report 2008 : SOCS1 silencing in DCs could prevent immune tolerance by inhibiting Fas and Fas-L expression, induced by an increase in IL-12p70 and IL-6 production
Kerkar et al., Mol Ther 2013 (Melanoma, Experimental) : Collapse of the Tumor Stroma is Triggered by IL-12 Induction of Fas ... Taken together, these results describe the likely requirement for costimulatory reverse signaling through Fasl on T cells that successfully infiltrate tumors, a mechanism triggered by the induction of Fas expression on myeloid derived cells by IL-12 and the subsequent collapse of the tumor stroma
Medvedev et al., Cytokine 1997 : IL-2 and IL-7 equally enhanced the Fas expression in the CD56+CD3+ population, while IL-12 had a less pronounced effect