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RELA — SPHK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RELA → SPHK1 (increases, SPHK1 Activity, RELA Activity) Kim et al., J Biol Chem 2001*
  Evidence: Incubation of HUVECs with 20 ng/ml VEGF-165 for 4 hours resulted in the sphingosine kinase-mediated increase in p65 subunit of NFKB activity. VEGF-induced p65 activation was found to be inhibited by 5 microM sphigosine kinase-inhibitor, DMS.

Text-mined interactions from Literome

Billich et al., Cell Signal 2005 : Suppression of SPHK1 activation led to reduction of cytokine induced IkappaBalpha phosphorylation and consequently diminished NFkappaB activity due to reduced nuclear translocation of RelA ( p65 ), explaining the dependence of inflammatory mediator production on SPHK1 activation
Gurgui et al., Cell Signal 2010 : Although our experimental data clearly show the mediatory role of sphingosine kinase ( SK ) -derived S1P in the TNF-alpha and the LPS induced activation of NF-kB , exogenously added S1P failed to trigger this transcription factor