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LEP — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bouloumie et al., FASEB J 1999
(Arteriosclerosis) :
NF-kappaB , another redox-sensitive transcription factor, was also
activated by
leptin stimulation in an oxidant dependent manner
Sitaraman et al., FASEB J 2004
(Colitis...) :
In
response to luminal
leptin , model intestinal epithelia critically activate the
NF-kappaB , a key signaling system to pro-inflammatory stimuli
Li et al., Diabetes 2005
:
In HASMCs,
leptin induced PKC, extracellular signal regulated kinase ( ERK ) 1/2, and
nuclear factor-kappaB (NF-kappaB) activation and inhibition of these signaling pathways abrogated HASMC proliferation and MMP-2 expression induced by this hormone ... Treatment of HASMCs with metformin decreased
leptin induced ROS production and activation of PKC, ERK1/2, and
NF-kappaB
Tang et al., J Immunol 2007
:
The binding of p65 and p50 to the
NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 and H4 acetylation on the IL-6 promoter was
enhanced by
leptin
Tong et al., Cell Signal 2008
(Arthritis, Rheumatoid...) :
The binding of p65 to the
NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 acetylation on the IL-8 promoter was
enhanced by
leptin , which was inhibited by wortmannin, Akt inhibitor or IRS-1 siRNA
Kanda et al., Endocrinology 2008
:
IL-1beta
enhanced the transcriptional activity of
NF-kappaB , whereas
leptin enhanced STAT1 and STAT3 activity
Jang et al., J Biol Chem 2010
(Anorexia) :
In addition, hypothalamic
NF-kappaB was
activated by
leptin , an important anorexigenic hormone, and mediates leptin stimulated POMC transcription, indicating that hypothalamic NF-kappaB also serves as a downstream signaling pathway of leptin
Gonzalez-Perez et al., Cell Signal 2010
(Mammary Neoplasms, Experimental) :
Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and
NFkappaB are
essentials for
leptin regulation of VEGF
Shi et al., Diabetologia 2013
(Inflammation) :
Finally, RELA binds to STAT3 and inhibits STAT3 mediated promoter activity, suggesting that
RELA , possibly together with forkhead box containing protein 1 ( FOXO1 ), may
prevent STAT3 mediated
leptin activation of the Pomc promoter