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RAC2 — RASGRF1
Text-mined interactions from Literome
Kiyono et al., J Biol Chem 2000
:
Tyrosine phosphorylation of
Ras-GRF1 is
critical for the induction of
Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates
Ras-GRF1 , thereby
inducing Rac-GEF activity ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates
Ras-GRF1 , thereby
inducing Rac-GEF activity
Drake et al., Genes, brain, and behavior 2011
:
Additional analyses of neonates showed imprinted Rasgrf1 transcript selective to olfactory bulb even in mice that were null for Rasgrf1 in the rest of the brain and showed that
Rasgrf1 affects Ras and
Rac activation in the brain
Talebian et al., J Mol Neurosci 2013
:
RasGrf1 can
activate both Ras and
Rac , via intrinsic Cdc25 and DH domains, respectively, suggesting that the activation of both could contribute to this process ... Moreover, we find that H-Ras over-expression rescues the loss of neurite outgrowth observed with a Rac minus mutant and that
RasGrf1 differentially
stimulates NGF dependent activation of
Rac or Ras, depending on cell type