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GNA15 — PLCB2

Pathways - manually collected, often from reviews:

• KEGG Chagas disease (American trypanosomiasis): GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Amoebiasis: GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• KEGG Calcium signaling pathway: GNA11/GNA14/GNA15/GNAQ → PLCB1/PLCB2/PLCB3/PLCB4 (protein-protein, activation)
• NCI Pathway Database IL8- and CXCR1-mediated signaling events: GNA15/GTP complex (GNA15) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Wu et al., Science 1993
  Evidence: genetic interaction
• NCI Pathway Database Endothelins: None → ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Plasma membrane estrogen receptor signaling: Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Le Mellay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database PAR1-mediated thrombin signaling events: Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Hung et al., J Biol Chem 1992
  Evidence: genetic interaction, other species
• NCI Pathway Database Endothelins: None → ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
  Evidence: assay, other species
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → p38 alpha (MAPK14) (modification, activates) Aquilla et al., J Biol Chem 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL8- and CXCR2-mediated signaling events: GNA15/GTP complex (GNA15) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, activates)
  Wu et al., Science 1993
  Evidence: genetic interaction
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
  Aramori et al., J Biol Chem 1992
• Reactome Reaction: GNA15 → PLCB2 (reaction) Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
• Reactome Reaction: GNA15 → PLCB2 (indirect_complex) Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006

Text-mined interactions from Literome

Yu et al., Journal of molecular signaling 2008 : Galpha16 can activate phospholipase Cbeta ( PLCbeta ) directly like Galphaq
Liu et al., Cell Signal 2010 : In contrast, these manipulations had no inhibitory effect on Galpha16QL induced activation of phospholipase Cbeta
Qian et al., J Biol Chem 1994 : Expression of the GTPase-deficient G alpha 16 polypeptide G alpha 16Q212L , a member of the Gq family of heterotrimeric G proteins, constitutively activated phospholipase C beta activity in Swiss 3T3 cells