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APC — SKP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Degradation of beta catenin: SCF complex (BTRC-SKP1-CUL1) → APC/beta catenin complex (APC-CTNNB1) (modification, activates)
  Hart et al., Curr Biol 1999, Kitagawa et al., EMBO J 1999, Winer et al., J Biol Chem 2006, Seo et al., Cell Signal 2009, Su et al., Mol Cell 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: SCF complex (BTRC-SKP1-CUL1) → APC (APC) (modification, activates) Hart et al., Curr Biol 1999, Kitagawa et al., EMBO J 1999, Winer et al., J Biol Chem 2006, Seo et al., Cell Signal 2009, Su et al., Mol Cell 2008
  Evidence: assay, physical interaction
• Reactome Reaction: SKP1 → APC (indirect_complex) Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
• Reactome Reaction: SKP1 → APC (reaction) Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999

Text-mined interactions from Literome

Kurland et al., Cancer Cell 2004 : Crashing waves of destruction : the cell cycle and APC ( Cdh1 ) regulation of SCF ( Skp2 )
Fukushima et al., Cell reports 2013 : Here, we continue to report that SCF ( ß-TRCP ) reciprocally controls APC/Cdh1 activity by governing Cdh1 ubiquitination and subsequent degradation