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EGF — NRP1
Text-mined interactions from Literome
Akagi et al., Br J Cancer 2003
(Stomach Neoplasms) :
Induction of
neuropilin-1 and vascular endothelial growth factor by
epidermal growth factor in human gastric cancer cells ... Moreover, in EGF-R positive NCI-N87 and ST-2 cells,
EGF induced both
NRP-1 and VEGF mRNA expression ... C225, a monoclonal antibody to EGF-R, blocked
EGF induced
NRP-1 and VEGF expression in NCI-N87 cells in a dose dependent manner ... Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line prevented
EGF induction of
NRP-1 and VEGF
Parikh et al., Cancer 2003
(Adenocarcinoma...) :
Expression and
regulation of the novel vascular endothelial growth factor receptor
neuropilin-1 by
epidermal growth factor in human pancreatic carcinoma ...
NRP-1 mRNA expression was
increased by
epidermal growth factor (EGF) but not by tumor necrosis factor alpha in several of the human pancreatic adenocarcinoma cell lines studied ... Blockade of the phosphatidylinositol-3 kinase (PI-3K)/Akt, mitogen activated protein kinase ( MAPK ) /Erk, or P-38 pathways abrogated
EGF induced
NRP-1 expression ... Finally,
EGF receptor blockade in vivo
led to a decrease in
NRP-1 expression in an orthotopic model of human pancreatic carcinoma ...
EGF regulates
NRP-1 expression through the PI-3K/Akt and MAPK/Erk signaling pathways, and blockade of the EGF receptor is associated with decreased expression of NRP-1 in vivo
Parikh et al., Am J Pathol 2004
(Adenocarcinoma...) :
Epidermal growth factor (EGF) led to induction of
NRP-1 in human colon adenocarcinoma cells and selective blockade of the epidermal growth factor receptor (EGFR) decreased constitutive and EGF induced NRP-1 expression ... Blockade of the Erk 1/2 and P38 mitogen activated protein kinase signaling pathways also led to a decrease in constitutive and
EGF induced
NRP-1 expression
Kurschat et al., J Biol Chem 2006
:
Epidermal growth factor (EGF) and heparin binding EGF-like growth factor ( HB-EGF ) strongly
up-regulated NRP1 expression, concomitant with down-regulation of NRSF