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PTGES — TNF
Text-mined interactions from Literome
Mustafa et al., J Clin Periodontol 2005
:
The cytokine
TNFalpha enhanced the expression of mRNA as well as the protein levels of both COX-2 and
mPGES-1 and subsequently the production of PGE2 in gingival fibroblasts ... Treatment of gingival fibroblasts with triclosan ( 1 microg/ml ) significantly reduced the stimulatory
effect of
TNFalpha ( 10 ng/ml ) on the expression of
mPGES-1 at both the mRNA and the protein level by an average of 21 % and 43 %, respectively, and subsequently the production of PGE2 ( p < 0.01 )
Yucel-Lindberg et al., Cell Signal 2006
:
The results showed that IL-1beta and
TNFalpha induce the expression of
mPGES-1 without inducing the expression of early growth response factor-1 (Egr-1)
Brenneis et al., FASEB J 2006
:
TNFalpha induced COX-2 and
mPGES-1 expression in neurons, followed by formation of PGE2, which was blocked by a selective COX-2 inhibitor ... SC-560 treatment neither altered
TNFalpha induced COX-2 or
mPGES-1 expression nor did the addition of the calcium ionophore A23187 or arachidonic acid reverse the inhibition by SC-560
Barakat et al., Naunyn Schmiedebergs Arch Pharmacol 2009
(Brain Ischemia...) :
Furthermore, OGD and the NF-kappaB activator
tumor necrosis factor stimulated the expression of cPLA-2, cyclooxygenase-2 (COX-2), and
mPGES-1 and increased the release of PGE ( 2 ) from neurons
Kunze et al., Prostaglandins Other Lipid Mediat 2010
(Inflammation) :
IL1beta,
TNF-alpha and LPS
enhanced the expression of COX-2 and
mPGES1 whereas phorbol ester enhanced COX-2 expression only
Båge et al., BMC genomics 2010
:
Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of
TNFalpha induced
mPGES-1 and COX-2 expression in gingival fibroblasts ... Inhibitors of JNK and NF-kappaB also decreased the
TNFalpha stimulated up-regulation of
mPGES-1 and COX-2 as well as PGE2 production
Waclawik et al., Reproduction 2010
:
TNF stimulated PTGS2 and mPGES-1 mRNA, as well as
mPGES-1 protein expression and PGE ( 2 ) release on days 11-12 of pregnancy and the estrous cycle
Brenneis et al., J Biol Chem 2011
(Disease Models, Animal...) :
Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced
tumor necrosis factor a (TNFa) synthesis and COX-2 and
mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Båge et al., Am J Pathol 2011
(Inflammation...) :
In
response to
tumor necrosis factor ( TNF-a ), IL-1ß, and cocultured lymphocytes, however,
mPGES-1 and COX-2 protein expression increased in fibroblasts and smooth muscle cells, accompanied by increased PGE ( 2 ), whereas mPGES-2 and cPGES were unaffected
Khan et al., J Immunol 2012
:
Matrix metalloproteinase dependent
microsomal prostaglandin E synthase-1 expression in macrophages :
role of
TNF-a and the EP4 prostanoid receptor
Piotrowska-Tomala et al., Domest Anim Endocrinol 2012
(Mastitis, Bovine) :
Lipopolysaccharides,
TNF , IL-1a, and the reagents combination
increased PTGS2,
PTGES , and PGFS mRNA transcription ( P < 0.01 ), whereas ALOX5 mRNA transcription was increased only by TNF ( P < 0.001 )