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CCL2 — IL12B
Text-mined interactions from Literome
DePaolo et al., J Immunol 2003
:
CC
chemokine ligand 2 and its receptor
regulate mucosal production of
IL-12 and TGF-beta in high dose oral tolerance
EnrĂquez-de-Salamanca et al., Cytokine 2008
(Conjunctivitis, Allergic...) :
TNF-alpha stimulated secretion of
IL-12p40 was significantly
increased by 30 min ; GM-CSF,
MCP-1 , IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Goodyear et al., J Immunol 2010
(Burkholderia Infections...) :
Production of
IL-12 and IFN-gamma in the lungs after B. mallei infection was significantly
impaired in both
MCP-1 ( -/- ) and CCR2 ( -/- ) mice, whereas treatment of CCR2 ( -/- ) mice with rIFN-gamma restored protection against lethal challenge with B. mallei
Seitz et al., Eur J Immunol 1996
:
In contrast,
IL-12 stimulated the production of IL-1 beta and
MCP-1 in TNF-alpha stimulated MNC and inhibited IL-1ra synthesis in cytokine stimulated cells
Chensue et al., J Immunol 1996
(Granuloma) :
In addition,
MCP-1 inhibited
IL-12 production by inflammatory macrophages
Karpus et al., J Exp Med 1998
(Encephalomyelitis, Autoimmune, Experimental) :
Increase in
MCP-1 expression
resulted in downregulation of mucosal
interleukin (IL)-12 expression with concomitant increase in mucosal IL-4 expression