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E2F5 — RBL2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
RBL2
—
E2F5
Sardet et al., Proc Natl Acad Sci U S A 1995*
-
IRef Bind_translation Interaction:
RBL2
—
E2F5
(two hybrid)
Sardet et al., Proc Natl Acad Sci U S A 1995*
-
IRef Biogrid Interaction:
RBL2
—
E2F5
(association, biochemical)
Hijmans et al., Mol Cell Biol 1995
-
IRef Biogrid Interaction:
RBL2
—
E2F5
(physical association, affinity chromatography technology)
Litovchick et al., Mol Cell 2007
-
IRef Biogrid Interaction:
RBL2
—
E2F5
(direct interaction, two hybrid)
Kong et al., Mol Cell 2006
-
MIPS CORUM pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2):
pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) complex (DNMT1-E2F5-HDAC1-RBL2-SUV39H1)
Macaluso et al., Oncogene 2003
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MIPS CORUM pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300):
pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) complex (E2F5-EP300-HDAC1-RBL2-SUV39H1)
Macaluso et al., Oncogene 2003
-
MIPS CORUM E2F5-RB2-DP1 complex:
E2F5-RB2-DP1 complex complex (E2F5-RBL2-TFDP1)
Hijmans et al., Mol Cell Biol 1995
-
IRef Corum Interaction:
Complex of 11 proteins
(association, far western blotting)
Macaluso et al., Oncogene 2003
-
IRef Corum Interaction:
Complex of RBL2-RBL2-TFDP1-TFDP1-E2F5-E2F5
(association, coimmunoprecipitation)
Hijmans et al., Mol Cell Biol 1995
-
IRef Corum Interaction:
Complex of 11 proteins
(association, far western blotting)
Macaluso et al., Oncogene 2003
-
Gene Ontology Complexes transcription factor complex:
transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
-
IRef Hprd Interaction:
Complex of 51 proteins
(in vivo)
Macaluso et al., Oncogene 2003
-
IRef Hprd Interaction:
Complex of E2F5-RBL2-E2F5-HDAC1-HDAC1-RBL2-HDAC1-E2F5-RBL2
(in vivo)
D'Souza et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of TFDP1-RBL2-E2F5-E2F5-RBL2-TFDP1-RBL2-E2F5-TFDP1
(in vivo)
Hijmans et al., Mol Cell Biol 1995
-
IRef Hprd Interaction:
E2F5
—
RBL2
(in vivo)
Chestukhin et al., Mol Cell Biol 2002*
-
IRef Hprd Interaction:
Complex of 51 proteins
(in vivo)
Macaluso et al., Oncogene 2003, Hijmans et al., Mol Cell Biol 1995
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti tag coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Intact Interaction:
Complex of 31 proteins
(association, anti bait coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Ophid Interaction:
RBL2
—
E2F5
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Wharton et al., J Biol Chem 2000
:
In contrast, p130 became partially phosphorylated, accompanied by a marked increase in
p130 dependent
E2F DNA binding activity and a partial release of free E2F-4
Yamada et al., Cytokine 2002
:
Our results indicate that blocking
E2F dependent transactivation, but not the formation of
p130-E2F transcriptional repressor complexes, is responsible for the inhibition of IL-3 dependent cell growth by p130
Genovese et al., Oncogene 2006
(Eye Neoplasms...) :
The mechanisms of transcriptional activation and repression by the Rb gene family has been extensively investigated : pRb,
pRb2/p130 and p107 interact with different E2F family factors and can
inhibit E2F responsive promoters, interfering with progression of cell cycle, gene transcription, initiation of apoptotic process and cell differentiation
Chen et al., Molecular vision 2008
:
Therefore, overexpression of E2F5/p130, but not E2F5 alone, can inhibit activator E2F mediated cell proliferation in vivo, confirming that
p130 plays a critical role in the repressive activity of
E2F5/p130 complex
Dingar et al., J Mol Cell Cardiol 2012
:
As analyzed by chromatin immunoprecipitation, the
E2F4-p130-repressor directly
blocks transcription of essential apoptosis related genes,
E2F1 , Apaf-1, and p73a through recruitment of histone deacetylase 1 (HDAC1)
Zalvide et al., Mol Cell Biol 1998
:
Furthermore, the J domain is required to override the repression of
E2F activity
mediated by
p130 and pRB and to disrupt p130-E2F DNA binding complexes