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NOTCH3 — SMN1
Text-mined interactions from Literome
Noseda et al., Circ Res 2006
:
Here, we show that
Notch directly
regulates expression of the mesenchymal and smooth muscle cell marker
smooth muscle alpha-actin (SMA) in endothelial and vascular smooth muscle cells via activation of its major effector, CSL ...
Notch/CSL activation
induces SMA expression during endothelial-to-mesenchymal transformation, and Notch activation is required for expression of SMA in vascular smooth muscle cells ... CSL directly binds a conserved cis element in the SMA promoter, and this consensus sequence is required for
Notch mediated
SMA induction
Tang et al., Circ Res 2008
:
The
Notch intracellular domain ( NotchICD ) forms a complex with CBF-1 ( C-promoter binding factor-1 ) and directly
induces SMA expression
Chen et al., Zhonghua Gan Zang Bing Za Zhi 2012
:
Notch3 mediated expression of the myo ? broblastic markers,
a-SMA and collagen I, was detected in HSC-T6 cells transfected with pcDNA3.1-N3ICD or Notch3 siRNA by Western blotting ... Transfection mediated over-expression of
Notch3 led to significantly increased expression of
a-SMA ( 6.8-fold, t = 13.157 ) and collagen I ( 5.5-fold, t = 9.810 ) ( both P less than 0.01 )
Zhang et al., Int J Biochem Cell Biol 2013
:
Moreover,
Notch stimulated expression of mature smooth muscle genes
SMA , MHC, SM22, and calponin, which define the physiologic phenotype of normal vascular smooth muscle, was inhibited by type IV collagen in A7R5 cells