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FOXP3 — NOTCH3

Text-mined interactions from Literome

Samon et al., Blood 2008 : Here, we show that pharmacologic inhibition of Notch signaling using gamma-secretase inhibitor (GSI) treatment blocks ( 1 ) TGFbeta1 induced Foxp3 expression, ( 2 ) the up-regulation of Foxp3-target genes, and ( 3 ) the ability to suppress naive T-cell proliferation ... Together, these findings indicate that the Notch and TGFbeta signaling pathways cooperatively regulate Foxp3 expression and regulatory T-cell maintenance both in vitro and in vivo
Ou-Yang et al., Mol Cell Biochem 2009 : As transcription factor Foxp3 acts as a master molecule governing the development and function of Tregs, we investigated whether Notch signaling might directly regulate Foxp3 expression
Campese et al., Int Immunol 2009 (Diabetes Mellitus, Type 1) : Moreover, by using double mutant mice, with T cell targeted constitutive activation of Notch3 in a pTalpha ( -/- ) background, we demonstrate that pTalpha deletion significantly counteracts the Notch3 dependent expansion, the increased FoxP3 expression and the enhanced in vitro activity of naturally occurring T ( reg ) s. Notably, the absence of pTalpha also impairs the Notch3 dependent protection against experimentally induced autoimmune diabetes