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FAS — PARP3
Text-mined interactions from Literome
Kobayashi et al., Arthritis Rheum 1999
(Osteoarthritis) :
In addition,
Fas ligation to TNFalpha treated cultured OA synoviocytes
induced activation of caspase 8 and caspase 3, with subsequent cleavage of poly ( ADP-ribose ) polymerase (
PARP ), a substrate of activated caspase 3
Shisler et al., Virology 2001
:
The MC159 expressing virus blocked
Fas induced activation of caspase-3 and -8, degradation of
PARP , and cleavage of DNA, whereas the parental vaccinia virus did not
Starcevic et al., J Natl Cancer Inst 2001
(Breast Neoplasms) :
Levels of proteins involved in
Fas mediated apoptosis and cleavage of poly ( adenosine diphosphate-ribose ) polymerase (
PARP ), an end product of caspase activation, were determined by immunoblotting
Wagenknecht et al., Cell Death Differ 2001
:
CD95L induced caspase 3-like activity, cytochrome c release and cleavage of caspases 3, 8, 9 and poly ( ADP-ribose ) polymerase (
PARP ) increase substantially after cotreatment with CD95L and C2-ceramide compared with CD95L treatment alone
Los et al., Mol Biol Cell 2002
(Necrosis) :
TNF but not
CD95 mediated
PARP activation, whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD
Mou et al., Int J Biochem Cell Biol 2013
(Neoplasms) :
Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound
Fas and Bax, reduced the expression of Bcl-2,
promoted the cleavage of caspases-8, -3, -9 and PARP, and the nuclear translocation of cleaved
PARP
Dou et al., J Cell Biochem 1997
:
Stimulation of
Fas by Fas ligand or agonistic antibodies
results in the activation of interleukin-1 beta converting enzyme-like ( ICE-like ) proteases, and proteolytic cleavage of poly ( ADP-ribose ) polymerase (
PARP )