◀ Back to WNT1

MAP3K7 — WNT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database C-MYB transcription factor network: WNT1 (WNT1) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Kanei-Ishii et al., Genes Dev 2004*

Text-mined interactions from Literome

Ishitani et al., Nature 1999 : These results raise the possibility that TAK1 and NLK are also involved in Wnt signalling in mammalian cells
Smit et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We find that Wnt1 stimulation results in autophosphorylation and activation of MOM-4/Tak1 in a TAP-1/Tab1 dependent fashion ... Wnt1 induced Tak1 stimulation activates Nemo-like kinase, resulting in the phosphorylation of TCF
Parker et al., Journal of the Association for Research in Otolaryngology : JARO 2011 : Functioning downstream of TGF-ß and BMP signaling, TAK1 mediates the activation of the c-Jun N-terminal kinase signaling pathway, serves as the target of pro-inflammatory cytokines, such as TNF-a, mediates NF-?ß activation, and plays a role in Wnt/Fz signaling in mesenchymal stem cells