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IL1A — NAIP
Text-mined interactions from Literome
Casson et al., PLoS Pathog 2013
:
Interestingly, whereas caspase-11 promotes IL-1ß release in response to the type IV secretion system through the NLRP3/ASC inflammasome, caspase-11 dependent release of
IL-1a is
independent of both the
NAIP5/NLRC4 and NLRP3/ASC inflammasomes as well as TRIF and type I interferon signaling
Lage et al., Proc Natl Acad Sci U S A 2013
(Salmonella Infections) :
NAIP5/NLRC4 ( neuronal apoptosis inhibitory protein 5/nucleotide oligomerization domain-like receptor family, caspase activation recruitment domain domain containing 4 ) inflammasome activation by cytosolic flagellin
results in caspase-1 mediated processing and secretion of
IL-1ß/IL-18 and pyroptosis, an inflammatory cell death pathway