Nishida et al., Arthritis Rheum 2000
:
IL-1alpha stimulated the expression of HAS-2 and CD44 mRNA ( 3.5-fold and 3-fold, respectively ), but inhibited the expression of aggrecan mRNA ... These data demonstrate that IL-1alpha stimulates HAS-2 at the same time as it inhibits the expression of aggrecan
Meran et al., Am J Pathol 2013
(MAP Kinase Signaling System) :
The aim of this study was to determine the significance of IL-1ß induced changes in HA and HAS-2 generation