◀ Back to CXCL12
ACKR3 — CXCL12
Pathways - manually collected, often from reviews:
-
KEGG Cytokine-cytokine receptor interaction:
CXCL12
→
ACKR3
(protein-protein, activation)
-
Reactome Reaction:
ACKR3
→
CXCL12
(direct_complex)
Balabanian et al., J Biol Chem 2005*, Dealwis et al., Proc Natl Acad Sci U S A 1998*
-
Reactome Reaction:
ACKR3
→
CXCL12
(reaction)
Balabanian et al., J Biol Chem 2005*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994, Dealwis et al., Proc Natl Acad Sci U S A 1998*
Text-mined interactions from Literome
Sierro et al., Proc Natl Acad Sci U S A 2007
:
CXCL12 did not
induce signaling through CXCR7 ; however,
CXCR7 formed functional heterodimers with CXCR4 and enhanced CXCL12 induced signaling
Luker et al., Neoplasia (New York, N.Y.) 2009
:
Using firefly luciferase protein fragment complementation, we established that chemokine ligands
CXCL12 and CXCL11 significantly
increase association of
CXCR7 and beta-arrestins with preferential interaction of the receptor with beta-arrestin 2
Melchionna et al., Muscle Nerve 2010
:
Western blot analysis and real-time polymerase chain reaction ( PCR ) were performed to evaluate in vitro the effect of
SDF-1 and CXCR4 and
CXCR7 inhibition on myogenic differentiation
Duda et al., Clin Cancer Res 2011
(Neoplasms) :
CXCL12 ( SDF1alpha )
-CXCR4/CXCR7 pathway
inhibition : an emerging sensitizer for anticancer therapies ?
Luker et al., Nat Med 2012
(Breast Neoplasms...) :
Studies established that small-molecule inhibitors of CXCR4 or
CXCR7 specifically
blocked CXCL12 binding in cell based assays and revealed differences in kinetics of inhibiting chemokine binding to each receptor
Rao et al., PloS one 2012
(Glioblastoma) :
Genetic manipulation of
CXCL12 expression and pharmacological
inhibition of its receptors CXCR4 and
CXCR7 revealed that the localizing and trophic effects of endothelial cells on GBM cells were dependent upon CXCL12 and CXCR4
Zhu et al., Stem Cells 2012
(MAP Kinase Signaling System) :
Using a primary hNPC culture system, we demonstrated that
CXCL12 promotes hNPC survival in the events of camptothecin induced apoptosis or growth factor deprivation, and that this effect
requires both
CXCR7 and CXCR4